69 products were found matching "I7661-25L.100"!

The insulin receptor is a tetrameric transmembranous glycoprotein composed of two alpha subunits (120kD) and two beta subunits (90kD). The alpha subunits are disulfide linked, totally extracellular and are the insulin binding site. The beta subunits are transmembranous and contain an intracellular tyrosine kinase...

The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide-linked subunits in a b-a-a-b configuration. The b-subunit (95kD) possesses a single transmembrane domain, whereas the a-subunit (135kD) is completely extracellular. Applications: Suitable for use in ELISA,...

IGF is a well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on Somatotropin. It is believed to be mainly active in adults in contrast to...

Applications: , Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and...

Type I insulin-like growth factor receptor (IGF1R), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the...

Type I insulin-like growth factor receptor (IGF1R, IGF-IR) is a transmembrane tyrosine kinase. It is widely expressed among many cell types in fetal and postnatal tissues and many cell lines. Upon binding of its ligands, IGF-I and IGF-II, autophosphorylation of receptors occurs. The triple tyrosine cluster (Tyr1131,...

Type I insulin-like growth factor receptor IGF-IR), a transmembrane tyrosine kinase, is widely expressed among many cell types in fetal and postnatal tissues, as well as many cell lines (1-3). Upon binding of its ligands, IGF-I and IGF-II, autophosphorylation of receptors occurs. The triple tyrosine cluster...

Applications: , Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: ELISA: 0.1ug/ml., Western Blot: 1ug/ml using HRPO/ECL detection. Recommended blocking buffer: Casein/Tween 20 based blocking and blot incubation buffer. Positive Control Included:...

The insulin receptor (InsR) is a heterodimeric receptor tyrosine kinase with an extracellular alpha-chain and a transmembrane and intracellular beta-chain. The insulin receptor is activated upon binding of the peptide hormone insulin, leading to autophosphorylation of tyrosine residues 1146, 1150, and 1151 in the...

Applications: , Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 0.1ug/ml, Western Blot: 0.5ug/ml for HRPO/ECL detection., Note: Recommanded blocking buffer CPPT: 0.5% casein, 1% PEG 4000, 1% polyvinypyrrolidone (PVP), 0.1% Tween 20, 10mM Tris/HCL, ph 7.4,...

Applications: , Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 detects phosphorylated IR (Tyr972) in RIPA lysates of untreated and insulin treated CHO cells transfected with IR., Optimal dilutions to be determined by the researcher. Recommended Secondary...

The insulin receptor is a tyrosine kinase receptor that when bound to insulin, initiates multiple signal transduction pathways, including JNK, PI 3-kinase, Akt and PKC. Pharmacological intervention of these Insulin R-dependent pathways is of great interest for the treatment of insulin resistance, obesity and...