Anti-IL3RB (CD131, Cytokine Receptor Common Subunit beta, CDw131, GM-CSF/IL-3/IL-5 Receptor Common b

CD131, also known as the IL-3R common B subunit (BC), is a 95-120kD type I transmembrane glycoprotein and belongs to the Ig superfamily. The common B subunit associates with the specific a subunits of IL-3 receptor, IL-5 receptor and GM-CSF receptor to form high affinity receptors for these cytokines. These cytokine receptors are expressed by neutrophils, eosinophils, monocytes, endothelial cells, fibroblasts and hematopoietic progenitor cells and play a crucial role in growth/activation of eosinophils and in the inflammatory response. This antibody is a non-Blocking antibody. Applications: Suitable for use in Flow Cytometry, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Flow Cytometry: <0.5ug/10e5 cells in 100ul, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.