Anti-IL12A (Interleukin-12 Subunit alpha, IL-12A, Cytotoxic Lymphocyte Maturation Factor 35kD Subuni

Interleukin 12 (IL-12) and interleukin 35 (IL-35) are heterodimeric cytokines composed of alpha and beta chains. IL-12 is composed of p35 and p40 subunits, while IL-35 is comprised of p35 paired with EBI-3. In mice, IL-35 is produced by FoxP3+ regulatory T cells and may function as an inhibitory cytokine to suppress T cell proliferation. Human FoxP3+ Tregs do not constitutively express IL-35, but expression may be induced by activated dendritic cells. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommened Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Carboxyfluorescein conjugates are sensitive to light.