10 products were found matching "Cay13782"!

Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids. It is produced from eicosapentaenoic acid (EPA, Cay-90110, Cay-90110.1, Cay-21908) via an 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in...

The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin (Cay-13346)) and regulate different pathways. WYE-125132 is an ATP-competitive inhibitor of mTOR...

A-66 is a potent, selective inhibitor of the PI3K isoform p110alpha (IC50 = 32 nM in a cell-free assay). It displays over 100-fold selectivity for p110alpha over other isoforms. A-66 is effective in vivo, suppressing the growth of SKOV3 tumor xenografts in mice. It also impairs all measures of in vivo insulin action...

Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 µM), to destabilize microtubules and disrupt mitosis. At 50 µM, it directly affects tubulin polymerization in Xenopus egg extracts without interfering with the activity of Cdk1, DNA replication, or actin...

JWH 149 (Cay-13978) is a synthetic cannabinoid (CB) which potently binds both the central CB1 receptor (Ki = 5.0 nM) and the peripheral CB2 receptor (Ki = 0.73 nM). Its physiological properties have not been elucidated. This product is intended for research and forensic applications.Formal Name:...

KL001 is a cryptochrome protein stabilizer. It inhibits ubiquitin-induced degradation of cryptochrome 1 (CRY1) in HEK293T cells overexpressing CRY1 when used at a concentration of 50 µM. KL001 (0.3-24 µM) lengthens the circadian period in U2OS human osteosarcoma cells in a reporter assay. It reduces glucagon-induced...

all-trans-4-hydroxy Retinoic acid is a metabolite of all-trans retinoic acid (Cay-11017) formed by the cytochrome P450 (CYP) isoforms CYP26A1, B1, and C1. It binds to retinoic acid receptors (RARs) with a lower affinity than other all-trans retinoic acid metabolites (IC50s = 606, 298, and 892 nM for RARalpha,...

hemi-Oxanthromicin A is a polyketide that has been found in Streptomyces.Formal Name: 9,10-dihydro-3,8,10-trihydroxy-1,7,10-trimethyl-9-oxo-2-anthracenecarboxylic acid. CAS Number: 91161-78-3. Molecular Formula: C18H16O6. Formula Weight: 328.3. Purity: >95%. Formulation: (Request formulation change), A solid....

FK-866 is a highly specific non-competitive inhibitor of Nampt (Ki = 0.4 nM), causing gradual NAD+ depletion. In HepG2 human liver carcinoma cells, NAD+ depletion by FK-866 directs delayed cell death by apoptosis (IC50 = ~1 nM). In normal human smooth muscle cells, FK-866 causes premature senescence, an effect that...

Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei. It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various...