- Search results for Cay19015-25
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13 products were found matching "Cay19015-25"!
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Item number: Cay19510-25
11-dehydro-2,3-dinor Thromboxane B2 (11-dehydro-2,3-dinor TXB2) is a metabolite of the TXA2 inactive metabolite TXB2 (Cay-19030). It is formed from TXB2 by cytosolic aldehyde dehydrogenase (ALDH) and beta-oxidation. Levels of 11-dehydro-2,3-dinor TXB2 are increased 5.2-fold in a surgery-induced rat model of tendon...
Keywords: | 11-dehydro-2,3-dinor TXB2, 9alpha,15S-dihydroxy-11-oxo-2,3-dinor-thromba-5Z,13E-dien-1-oic acid |
Application: | TXB2 metabolite |
CAS | 79250-60-5 |
MW: | 340.4 D |
From 60.00€
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Item number: Cay19152-5
MKC-3946 is an inhibitor of inositol-requiring enzyme 1alpha (IRE1alpha). It inhibits basal XBP1 splicing, a marker of IRE1alpha activity, in RPMI 8226 multiple myeloma cells in a concentration-dependent manner. MKC-3946 also inhibits XBP1 splicing induced by endoplasmic reticulum (ER) stress and reduces expression...
Keywords: | 2-hydroxy-6-[5-[(4-methyl-1-piperazinyl)carbonyl]-2-thienyl]-1-naphthalenecarboxaldehyde |
Application: | IRE1alpha inhibitor |
CAS | 1093119-54-0 |
MW: | 380.5 D |
From 76.00€
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Item number: Cay19025-10
SQ 29,548 is a highly selective TP receptor antagonist which binds to the human recombinant TP receptor with a Ki of 4.1 nM. It inhibits the aggregation of washed human platelets induced by U-46619 with an IC50 of 0.06 µM. It antagonizes U-46619 induced contraction of rat and guinea pig tracheal, arterial, and...
Keywords: | [1S-[1alpha,2alpha(Z),3alpha,4alpha]]-7-[3-[[2-[(phenylamino)carbonyl]hydrazino]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-he... |
Application: | TP receptor antagonist |
CAS | 98672-91-4 |
MW: | 387.5 D |
From 114.00€
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Item number: Cay10009215-25
9-OxoOTrE is produced by the oxidation of 9-HpOTrE. 9-OxoOTrE exhibits antimicrobial activity against plant pathogenic microorganisms including bacteria and fungi.Formal Name: 9-oxo-10E,12Z,15Z-octadecatrienoic acid. CAS Number: 125559-74-2. Synonyms: 9-KOTE, 9-KOTrE. Molecular Formula: C18H28O3. Formula Weight:...
Keywords: | 9-KOTE, 9-KOTrE, 9-oxo-10E,12Z,15Z-octadecatrienoic acid |
Application: | Bioactive lipid assays |
CAS | 125559-74-2 |
MW: | 292.4 D |
From 109.00€
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Item number: Cay10009815-25
Pleckstrin homology (PH) domains all contain a seven-standard b-sandwich that allows binding to various species of phosphatidylinositol (PtdIns) phosphates. Most PH domains bind to PtdIns phosphates with weak affinity and low specificity. However, a small subclass binds specifically and with high-affinity for...
Keywords: | Phosphatidylinositol-4,5-diphosphate, PI(4,5)-P2, PIP2, PLC-delta1-PH Domain |
Application: | WB |
MW: | 45,2 kD |
From 163.00€
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Item number: Cay19310-25
AZ 7371 is a non-covalent inhibitor of decaprenylphosphoryl-beta-D-ribose 2'-epimerase (DprE1, IC50 = 10 nM), an enzyme involved in mycobacterial cell wall biogenesis. It inhibits wild-type M. smegmatis DprE1 and DprE1 harboring the drug-resistance mutation C394G (IC50 = 0.01 µM for both) but not the Y321H mutation...
Keywords: | N-(2-hydroxyethyl)-1-[(6-methoxy-5-methyl-4-pyrimidinyl)methyl]-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide |
Application: | DprE1 inhibitor |
CAS | 1494675-86-3 |
MW: | 355.4 D |
From 60.00€
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Item number: Cay19710-25
Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2, IC50 = 0.05 µM). It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 µM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-alpha production in isolated human monocytes and whole...
Keywords: | c-Cot Kinase Inhibitor, MAP3K8 Kinase Inhibitor, Tumor Progression Locus 2 Kinase Inhibitor,... |
Application: | c-Cot (MAP3K8) inhibitor |
CAS | 871307-18-5 |
MW: | 404.8 D |
From 77.00€
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Item number: Cay39015-25
GNE-140 is an inhibitor of lactate dehydrogenase A (LDHA) and LDHB (IC50s = 3 and 5 nM, respectively). It reduces lactate production in MiaPaCa-2 pancreatic cancer cells (IC50 = 670 nM). GNE-140 decreases proliferation in a panel of 37 cancer cell lines when used at a concentration of 5 µM.Formal Name:...
Keywords: | 3-[(2-chlorophenyl)thio]-5,6R-dihydro-4-hydroxy-6-[4-(4-morpholinyl)phenyl]-6-(3-thienyl)-2(1H)-pyridinone |
Application: | LDHA/LDHB inhibitor |
CAS | 2003234-63-5 |
MW: | 499 D |
From 127.00€
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Item number: Cay19525-10
Cyclosporin B is a minor cyclopeptide metabolite produced by T. polysporum and other deuteromycota with diverse biological activities. It inhibits the growth of T lymphoma cells in a concentration-dependent manner. Cyclosporin B also inhibits P-glycoprotein (P-gp) activity in vitro with an IC50 value of 4.7...
Keywords: | Antibiotic S 7481F2, 7-L-alanine-cyclosporin A |
Application: | Antibiotic |
CAS | 63775-95-1 |
MW: | 1188.6 D |
From 62.00€
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Item number: Cay19150-25
SKF 38393 is a partial agonist of the dopamine D1-like receptors D1 and D5 (Kis = 1 and ~0.5 nM, respectively). It less potently binds D2, D3, and D4 receptors (Kis = ~150, 5,000, and 1,000 nM, respectively).Formal Name: 2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol, monohydrobromide. CAS Number: 20012-10-6....
Keywords: | 2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol, monohydrobromide |
Application: | D1 / D5 dopamine receptor selective partial agonist |
CAS | 20012-10-6 |
MW: | 336.2 D |
From 48.00€
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Item number: Cay11590-25
Rapamycin (Cay-13346) is an immunosuppressant that specifically interacts with the cytosolic FK-binding protein 12 to form a complex which inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding to mTOR Complex 1. Temsirolimus is a dihydroxymethyl propionic acid ester of rapamycin with improved...
Keywords: | CCI-779, Torisel(R), 42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate] rapamycin |
Application: | mTOR inhibitor, immunsuppressant, apoptosis inducer |
CAS | 162635-04-3 |
MW: | 1030.3 D |
From 77.00€
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Item number: Cay29015-25
INH1 is an inhibitor of the interaction between the oncogene high expression in cancer 1 (Hec1) and its regulator, the serine/threonine kinase Nek2. It binds to Hec1 and reduces Nek2 protein levels in HeLa cells when used at a concentration of 25 µM. INH1 inhibits the growth of MDA-MB-468, SK-BR-3, T47D, MDA-MB-361,...
Keywords: | IBT 13131, N-[4-(2,4-dimethylphenyl)-2-thiazolyl]-benzamide |
Application: | Hec1 /Nek2 interaction inhibitor |
CAS | 313553-47-8 |
MW: | 308.4 D |
From 77.00€
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