9 products were found matching "Cay15481-25"!

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Nobiletin
Nobiletin

Item number: Cay15421-5

Nobiletin is a polymethoxylated flavonoid that has been found in C. unshiu and has diverse biological activities. It reduces LPS- and IFN-gamma-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at concentrations of 25, 50, and 100 µM. Nobiletin...
Keywords: NSC 618903, NSC 76751, 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one
Application: Natural polymethoxylated flavonoid
CAS 478-01-3
MW: 402.4 D
From 48.00€ *
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ML-213
ML-213

Item number: Cay15185-25

The KCNQ (Kv7) family of voltage-gated potassium (K+) channels consists of five members, KCNQ1-KCNQ5. KCNQ1-KCNQ5 are critical for setting up the excitation threshold of action potentials. KCNQ1 is expressed mainly in cardiac tissue, peripheral epithelial cells, and smooth muscle cells, while KCNQ2-KCNQ5 are...
Keywords: CID-3111211, N-(2,4,6-trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide
Application: KCNQ2 / KCNQ4 activator
CAS 489402-47-3
MW: 257.4 D
From 92.00€ *
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Ticagrelor
Ticagrelor

Item number: Cay15425-25

Ticagrelor is a reversible antagonist of the platelet purinergic P2Y12 receptor (Ki = 14 nM, IC50 = 1.8 µM), which is the main receptor responsible for ADP-induced platelet aggregation. It functions by directly changing the conformation of the P2Y12 receptor to inhibit ADP binding. Formulations containing ticagrelor...
Keywords: AR-C 126532XX, AZD 6140,...
Application: P2Y12 receptor antagonist
CAS 274693-27-5
MW: 522.6 D
From 43.00€ *
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Carvedilol
Carvedilol

Item number: Cay15418-250

Carvedilol is an antagonist of the beta-adrenergic receptor (beta-AR, Kds = 1.78, 0.4, and 5.01 nM for beta1-, beta2-, and beta3-ARs, respectively). It also selectively binds to alpha1- over alpha2-ARs (Kis = 0.81 and 3,400 nM, respectively). Carvedilol reverses increases in heart rate induced by the beta1-AR...
Keywords: BM 14190, 1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol
Application: alpha1 / beta adrenergic receptor antagonist
CAS 72956-09-3
MW: 406.5 D
From 43.00€ *
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alpha-NETA
alpha-NETA

Item number: Cay15125-25

Choline acetyltransferase (ChAT) mediates the synthesis of the neurotransmitter acetylcholine from acetyl-CoA and choline. In addition to its critical role in neurosignaling, deficiencies in ChAT are linked to congenital myasthenic syndromes, Alzheimer's disease, and multiple sclerosis. alpha-NETA is a stable,...
Keywords: N,N,N-trimethyl-gamma-oxo-2-naphthalenepropanaminium, monoiodide
Application: Choline acetyltransferase (ChAT) inhibitor
CAS 31059-54-8
MW: 369.2 D
From 60.00€ *
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NMDA
NMDA

Item number: Cay14581-250

NMDA is a synthetic amino acid derivative that acts as a specific agonist at the NMDA receptor, mimicking the excitatory action of the endogenous ligand glutamate. Signaling through the NMDA receptor influences both neuronal plasticity and neurotoxicity. Repetitive activation of NMDA synapses leads to long-term...
Keywords: N-Methyl-D-Aspartic Acid, N-methyl-D-aspartic acid
Application: NMDA receptor agonist
CAS 6384-92-5
MW: 147.1 D
From 82.00€ *
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Abiraterone Acetate
Abiraterone Acetate

Item number: Cay15148-25

Abiraterone acetate is an inhibitor of the cytochrome P450 (CYP) isoform CYP17A1 (IC50s = 17 and 18 nM for inhibition of C17,20-lyase and 17alpha-hydroxylase activities, respectively). It is also a prodrug form of abiraterone (Cay-9002768). Abiraterone acetate reduces plasma testosterone levels, increases plasma...
Keywords: CB-7630, (3beta)-17-(3-pyridinyl)-androsta-5,16-dien-3-ol, acetate ester
Application: CYP17A1 blocking
CAS 154229-18-2
MW: 391.6 D
From 163.00€ *
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Pirinixic Acid Aminothiazole
Pirinixic Acid Aminothiazole

Item number: Cay15483-25

Microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO) are key enzymes in the synthesis of PGE2 (Cay-14010) and leukotrienes (LTs), respectively. PGE2 and LTs are bioactive lipids that contribute to a broad range of pathologies, including inflammation and various forms of cancer. Pirinixic acid...
Keywords: 2-[[4-chloro-6-[[4-(2-naphthalenyl)-2-thiazolyl]amino]-2-pyrimidinyl]thio]-octanoic acid
Application: mPGES-1 & 5-LO inhibitor
CAS 1492060-44-2
MW: 513.1 D
From 98.00€ *
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SP2509
SP2509

Item number: Cay15487-25

Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4), resulting in transcriptional repression. SP2509 is a reversible inhibitor of LSD1 (IC50 = 13 nM). It has no effect on monoamine oxidases A and B. SP2509 attenuates the binding of LSD1 to...
Keywords: HCI-2509, LSD1 Inhibitor VII, 3-(4-morpholinylsulfonyl)-benzoic acid (2E)-2-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazide
Application: LSD1 inhibitor
CAS 1423715-09-6
MW: 437.9 D
From 43.00€ *
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