Anti-Glutathione S Transferase, pi (GSTP1, GSTpi1, GST3, DFN7)

Anti-Glutathione S Transferase, pi (GSTP1, GSTpi1, GST3, DFN7)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
G8135-25C.100 100 µg - -

3 - 19 business days*

644.00€
 
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in... more
Product information "Anti-Glutathione S Transferase, pi (GSTP1, GSTpi1, GST3, DFN7)"
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta (reviewed in 1). The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism (i.e., the metabolism of environmental mutagens and carcinogens) and may play a role in susceptibility to cancer (2). More recent experiments have suggested that differential expression of GSTP1 also contributes to the sensitivity of xenobiotics in the substantia nigra and may influence the pathogenesis of reactive oxygen species-induced neurological disorders such as Parkinson's disease (3). CpG island hypermethylation of the GSTP1 promoter leading to the silencing of the GSTP1 gene has also been linked to cancer (4). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: EC=2.5.1.18, Anti-FAEES3, Anti-GSTP1-1, Anti-GST class-pi, Anti-Glutathione S-transferase P
Supplier: United States Biological
Supplier-Nr: G8135-25C

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Synthetic peptide corresponding to 14aa from near the center of human GSTP1 (Genbank accession No. NP_000843).
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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