9 products were found matching "Cay10600"!

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative,...

Indole-3-amidoxime is a synthetic intermediate useful for pharmaceutical synthesis.Formal Name: N-hydroxy-1H-indole-3-carboximidamide. CAS Number: 95649-37-9. Molecular Formula: C9H9N3O. Formula Weight: 175.2. Purity: >97%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 12.5 mg/ml,...

Many of the products generated by alkylating agents on DNA can be efficiently repaired by normal base excision repair (BER). Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in BER. Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM,...

Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. SAHA-BPyne is a SAHA derivative with a benzophenone crosslinker and an alkyne tag intended to be used for profiling HDAC...

Hormone-sensitive lipase (HSL) is a key enzyme regulating the mobilization of fatty acids from intracellular stores. There are three different isoforms of the enzyme: HSLadi, which is the predominant form found in adipocytes, HSLtes expressed in testes, and HSLb found in insulin secreting beta-cells. The three...

F-amidine is an inhibitor of protein arginine deiminases (PADs) that is selective for PAD1 and PAD4 (IC50s = 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4 in vitro, respectively). It irreversibly inactivates all four PAD subtypes (kinact/KI = 2,800, 380, 170, and 3,000 M-1min-1 by covalently modifying an active...

URB937 is a potent fatty acid amide hydrolase (FAAH) inhibitor (IC50 = 26.8 nM, in vitro) that does not penetrate the blood-brain barrier, thus preventing arachidonoyl ethanolamide (AEA, Cay-90050) deactivation only in peripheral tissues. Its ED50 value for FAAH inhibition in brain is 200-fold higher than the ED50...

dinor-12-oxo Phytodienoic acid-d5 (dinor-OPDA-d5) contains five deuterium atoms at the 4, 4', 5, 5, and 5 positions. It is intended for use as an internal standard for the quantification of dinor-OPDA by GC- or LC-mass spectrometry (MS). In plants, certain unsaturated fatty acids are oxygenated and then further...

Corey prostaglandin (PG)-lactone diol is a versatile, chiral intermediate used in the preparation of PGs and PG analogs. ent-Corey PG-lactone diol is the opposite enantiomer of corey PG-lactone diol.Formal Name: (6aR)-5S-hydroxy-4S-((R,E)-3aS-hydroxyoct-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one. CAS Number:...