Anti-FABP3 (Clone CC68)

Fatty acid binding protein 3 (FABP3) is one of nine known cytosolic FABPs ranging in size from 14-15 kDa containing 127-132 amino acids. Members of this protein family exhibit high affinity for small lipophilic ligands and were named according to the tissue from which they were initially isolated. Studies suggest that FABPs are involved in the uptake and metabolism of fatty acids, in the maintenance of cellular membrane fatty acid levels, in intracellular trafficking of these substrates, in the modulation of specific enzymes of lipid metabolic pathways, and in the modulation of cell growth and differentiation. FABP family members have highly conserved three dimensional structures and 22-73% amino acid sequence similarity. FABP3 is composed of ten antiparallel beta strands that form a barrel and is the most widely distributed FABP. It is found in heart, skeletal and smooth muscle, mammary epithelial cells, aorta, distal tubules of the kidney, lung, brain, placenta, and ovary. FABP3 is a potential biomarker for myocardial injury, especially for early detection of acute myocardial infarction (AMI).Synonyms: Cardiac FABP, Fatty acid binding protein 3, Heart fatty acid binding protein, H-FABP. Immunogen: Synthetic peptide from human FABP3 amino acids 44-55. Clone Designation: CC68. Formulation: (Request formulation change), 200 µg of affinity-purified monoclonal antibody. Storage Buffer: 200 µl PBS, pH 7.2 with 50% glycerol and 0.02% sodium azide. Host: Mouse. Isotype: IgG2b. Applications: WB. Cross Reactivity: (-) Mouse FABP1, (-) Mouse FABP2, (-) Mouse FABP4, (-) Mouse FABP5. Origin: Animal/Mouse.