Anti-Factor VIIIc (antihaemophilic factor)

Anti-Factor VIIIc (antihaemophilic factor)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
F0016-30.1 1 mg - -

3 - 19 business days*

393.00€
F0016-30.10 10 mg - -

3 - 19 business days*

757.00€
 
Factor VIII (antihemophilic globulin and Factor VIII:C) is a large glycoprotein (320kD) that... more
Product information "Anti-Factor VIIIc (antihaemophilic factor)"
Factor VIII (antihemophilic globulin and Factor VIII:C) is a large glycoprotein (320kD) that circulates in plasma at ~200ng/ml. Synthesized in the liver, the majority of Factor VIII is cleaved during expression, resulting in a heterogeneous mixture of partially cleaved forms of F.VIII ranging in size from 200-280kD. The F.VIII is stabilized by association with von Willebrand Factor to form a F.VIII-vWF complex required for the normal survival of F.VIII in vivo (t1/2 of 8-12 hours). F.VIII is a pro-cofactor that is activated through limited proteolysis by thrombin. In this process F.VIIIa dissociates from vWF to combine with activated Factor IX, calcium and a phospholipid surface where it is an essential cofactor in the assembly of the Factor X activator complex. Once dissociated from vWF, F.VIIIa is susceptible to inactivation by activated Protein C and by non-enzymatic decay., Hemophilia A is a congenital bleeding disorder resulting from an X-chromosome-linked deficiency of F.VIII. The severity of the deficiency generally correlates with the severity of the disease. Some Hemophiliacs (~10%) produce a F.VIII protein that is partially or totally inactive. The production of neutralizing antibodies to F.VIII also occurs in 5-20% of Hemophiliacs. Application: Suitable for use in ELISA, Immunoelectrophoresis and Neutralization. Other applications not tested. Recommended Dilutions: Neutralization: One Bethesda unit/ml is defined as the amount of inhibitor that resulted in 50% residual F.VIII activity after 2 hours at 37ºC., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-F8, Anti-F8C, Anti-AHF, Anti-Antihemophilic factor, Anti-Procoagulant component, Anti-Coagulation factor VIII
Supplier: United States Biological
Supplier-Nr: F0016-30

Properties

Application: ELISA, Neutr.
Antibody Type: Polyclonal
Conjugate: No
Host: Sheep
Species reactivity: human
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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