Anti-FHIT

Anti-FHIT
Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-BE6 100 µg - -

6 - 10 business days*

684.00€
 
Anti-FHIT Antibody was affinity purified from monospecific antiserum by immunoaffinity... more
Product information "Anti-FHIT"
Anti-FHIT Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. FHIT antibody is human and mouse reactive. Protein function: Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'- adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low- affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor. [The UniProt Consortium]
Keywords: Anti-FHIT, Anti-AP3Aase, EC=3.6.1.29, Anti-AP3A hydrolase, Anti-Dinucleosidetriphosphatase, Anti-Bis(5'-adenosyl)-triphosphatase, Anti-Fragile histidine triad protein, Anti-Diadenosine 5',5'''-P1,P3-triphosphate hydrolase
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-BE6

Properties

Application: ELISA, IFM, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Immunogen: 18 amino acid peptide near the C-terminus of human FHIT.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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