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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
600-401-BE6 | 100 µg | - | - |
6 - 10 business days* |
684.00€
|
Anti-FHIT Antibody was affinity purified from monospecific antiserum by immunoaffinity... more
Product information "Anti-FHIT"
Anti-FHIT Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. FHIT antibody is human and mouse reactive. Protein function: Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'- adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low- affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor. [The UniProt Consortium]
Keywords: | Anti-FHIT, Anti-AP3Aase, EC=3.6.1.29, Anti-AP3A hydrolase, Anti-Dinucleosidetriphosphatase, Anti-Bis(5'-adenosyl)-triphosphatase, Anti-Fragile histidine triad protein, Anti-Diadenosine 5',5'''-P1,P3-triphosphate hydrolase |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 600-401-BE6 |
Properties
Application: | ELISA, IFM, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | 18 amino acid peptide near the C-terminus of human FHIT. |
Format: | Purified |
Database Information
KEGG ID : | K01522 | Matching products |
UniProt ID : | P49789 | Matching products |
Gene ID | GeneID 2272 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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