Anti-ErbB2

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A300-623A 100 µl -

2 - 8 business days*

588.00€
 
Protein function: Protein tyrosine kinase that is part of several cell surface receptor... more
Product information "Anti-ErbB2"
Protein function: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. [The UniProt Consortium]
Keywords: Anti-HER2, Anti-CD340, Anti-ERBB2, Anti-MLN 19, Anti-p185erbB2, EC=2.7.10.1, Anti-Proto-oncogene Neu, Anti-Proto-oncogene c-ErbB-2, Anti-Metastatic lymph node gene 19 protein, Anti-Receptor tyrosine-protein kinase erbB-2
Supplier: Bethyl Laboratories
Supplier-Nr: A300-623A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: mouse, rat, dog, golden hamster)
Immunogen: synthetic peptide. The epitope recognized by A300-623A maps to a region between residue 1200 and the C-terminus (residue 1255) of human v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 using the numbering given in entry NP_004439.2 (GeneID 2064).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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