The EZH2 gene is a homolog of the Drosophila Polycomb group (Pc-G) gene enhancer of zeste, which is a crucial regulator of homeotic gene expression during embryonic development. The human homolog EZH2 (also known as ENX1) was initially isolated in a search for proteins that interact with Vav, a human proto-oncogene...

EZH2 (enhancer of zeste homolog 2), also known as Enx1, is a member of the polycomb group of proteins and is involved in cell cycle regulation. EZH2 represses transcription via trimethylation of histone H3 on Lys27 (H3K27) as indicated by the fact that RNAi-mediated knockdown of EZH2 resulted in a loss of H3K27...

The polycomb group (PcG) proteins are involved in maintaining the silenced state of several developmentally regulated genes and contribute to the maintenance of cell identity, cell cycle regulation, and oncogenesis (1,2). Enhancer of zeste homolog 2 (Ezh2), a member of this large, protein family, contains four...

EZH1 encodes a protein of 747aa that displays 55%aa identity overall with the Drosophila homolog. The strong sequence conservation suggested potential roles for EZH1 in human development as a transcriptional regulator and as a component of protein complexes that preserve heterochromatin stability. EZH1 is expressed...

EZH1 encodes a protein of 747 amino acids that displays 55% amino acid identity overall with the Drosophila homolog. The strong sequence conservation suggested potential roles for EZH1 in human development as a transcriptional regulator and as a component of protein complexes that preserve heterochromatin stability....