8 products were found matching "500-ERK"!
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ERK Inhibitor
Item number: Cay15944-500
ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 µM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect...
| Keywords: | Extracellular Regulated Kinase Inhibitor, 3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,... |
| Application: | MAPK1 / MAPK3 inhibitor |
| CAS | 1049738-54-6 |
| MW: | 328.8 D |
From 43.00€
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ASTX029
Item number: Cay33557-500
ASTX029 is an ERK inhibitor (IC50 = 2.7 nM for ERK2). It is selective for ERK over a panel of 465 kinases. ASTX029 reduces phosphorylation of p90 ribosomal S6 kinase (RSK) in mutant B-RAF-expressing A375 melanoma and mutant K-Ras-expressing HCT116 colorectal cancer cells with IC50 values of 3.3 and 4 nM,...
| Keywords: | (alphaR)-6-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethy... |
| Application: | ERK inhibitor |
| CAS | 2095719-92-7 |
| MW: | 584 D |
From 84.00€
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CAY10561
Item number: Cay10010043-500
The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is...
| Keywords: | Pyrazolylpyrrole ERK Inhibitor,... |
| Application: | ERK2 inhibitor |
| CAS | 933786-58-4 |
| MW: | 459.3 D |
From 35.00€
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MAP Kinase 12, Recombinant, Human, aa1-367, His-tag...
Item number: 029667.500
MAPK12, belongs to the MAP kinase family. MAPK12 functions as a signal transducer during differentiation of myoblasts to myotubes. Expressed in different areas throughout the body with common expression patterns in heart, p38 proteins use magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of...
| Keywords: | ERK6, ERK-6, MAPK12, MAPK 12, EC=2.7.11.24, MAP kinase 12, MAP kinase p38 gamma, Stress-activated protein kinase 3,... |
| Origin: | human |
From 568.00€
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MAP Kinase 3, aa1-379, Recombinant, Human...
Item number: M2360-02V.500
MAPK 1 is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This...
| Keywords: | ERT2, ERK1, ERK-1, MAPK3, MAPK 3, p44-MAPK, p44-ERK1, MAP kinase 3, EC=2.7.11.24, MAP kinase isoform p44,... |
| Origin: | human |
From 568.00€
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ERGi-USU
Item number: Cay30875-500
ERGi-USU is an inhibitor of the oncoprotein ETS-related gene (ERG, IC50 = 315 nM). It inhibits proliferation of ERG-expressing VCaP prostate, COLO 320 colon, and KG-1 and MOLT-4 leukemia cancer cells (IC50s = 30-400 nM) but not LNCaP, LAPC4, and MDA PCa 2b prostate cancer and human umbilical vein endothelial cells...
| Keywords: | NSC 139021, 1-[2-(2-thiazolyl)diazenyl]-2-naphthalenol |
| Application: | Transcriptional regulator ERG inhibitor |
| CAS | 1147-56-4 |
| MW: | 255.3 D |
From 44.00€
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Norepinephrine Bitartrate
Item number: LKT-N5766.500
Norepinephrine activates protein kinases Erk1/2. It is cytotoxic to human promyelocytic leukemic HL-60 cells.
| Application: | Erk1/2 activator |
| CAS | 69815-49-2 |
| MW: | 319,26 D |
From 189.00€
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