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Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A300-649A-T | 10 µl (10 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A300-649A | 100 µl (100 µg) | - |
2 - 8 business days* |
588.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Transcriptional repressor involved in the regulation of the circadian rhythm by... more
Product information "Anti-DEC1"
Protein function: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1, ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway. [The UniProt Consortium]
Keywords: | Anti-BHLHB2 protein, Anti-Basic helix-loop-helix domain-containing, Anti-Basic helix-loop-helix domain containing, class B, 2, isoform CRA_a, Anti-cDNA, FLJ92873, Homo sapiens basic helix-loop-helix domain containing, class B, 2(BHLHB2), mRNA |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A300-649A |
Properties
Application: | WB, IP, IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: orangutan) |
Immunogen: | synthetic peptide. The epitope recognized by A300-649A maps to a region between residues 350 and the C-terminus (residue 412) of human Differentially Expressed in Chondrocytes using the numbering given in entry NP_003661.1 (GeneID 8553). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K03729 | Matching products |
UniProt ID : | Q6IB83 | Matching products |
Gene ID | GeneID 8553 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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