Anti-Cul4a (IHC)

Anti-Cul4a (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00145-T 10 µl (1 µg) -

2 - 8 business days*

164.00€
IHC-00145 100 µl (10 µg) -

2 - 8 business days*

623.00€
 
Protein function: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase... more
Product information "Anti-Cul4a (IHC)"
Protein function: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL. [The UniProt Consortium]
Keywords: Anti-CUL4A, Anti-CUL-4A, Anti-Cullin-4A
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00145

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: chicken, turkey, dog, horse, rabbit, panda, monkey, gorilla, chimpanzee, african elephant, gray short-tailed opossum)
Immunogen: synthetic peptide. The epitope recognized by IHC-00145 maps to a region between residues 700 and the C-terminus (residue 759) of human Cullin 4A using the numbering given in entry NP_001008895.1 (GeneID 8451).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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