16 products were found matching "Cay13703-100"!

15(S)-15-methyl Prostaglandin E1 (15(S)-15-methyl PGE1) is a metabolically stable synthetic analog of PGE1 (Cay-13010). In sharp contrast to the bronchodilatory effects of PGE1, 15(S)-15-methyl PGE1 is a weak constrictor of human respiratory tract smooth muscle.Formal Name:...

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells and their main function is to...

Mesoridazine is an active metabolite of the typical antipsychotic thioridazine (Cay-14400). It is formed via sulfoxidation of thioridazine by the cytochrome P450 (CYP) isoform CYP2D6 in human liver microsomes. It binds to histamine H1, dopamine D2, muscarinic acetylcholine, and alpha1- and alpha2-adrenergic...

Esomeprazole is an inhibitor of the gastric H+/K+-ATPase and the (S) enantiomer of omeprazole (Cay-14880). It reversibly inhibits the activity of the H+/K+-ATPase in an enzyme assay. Esomeprazole (30 mg/kg, s.c.) inhibits histamine-induced gastric acid secretion in rats. Formulations containing esomeprazole in...

Influenza A nucleoprotein is a viral protein encoded by the NP gene in influenza A RNA. It is composed of an RNA-binding domain, oligomerization domains, and polymerase binding domains, and contains two nuclear localization signals and a cytoplasmic accumulation signal, which interacts with host actin. Influenza A...

(±)-CP 55,940-d11 is intended for use as an internal standard for the quantification of (±)-CP 55,940 (Cay-13241) by GC- or LC-MS. (±)-CP 55,940 is categorized as a synthetic cannabinoid. It induces self-administration of morphine in rats. This product is intended for research and forensic applications.Formal Name:...

L-Arginine is an amino acid and precursor of nitric oxide (NO). L-Arginine is a substrate for NO synthase that is oxidized to form NO and L-citrulline. It enhances NO release in porcine aortic endothelial cells treated with bradykinin (Cay-37408) or A23187 (Cay-11016). L-Arginine (30 and 300 mg/kg, i.v.) induces...

Zeaxanthin dipalmitate is a carotenoid that has been found in F. lycii and has hepatoprotective activity. It inhibits TGF-beta-induced activation of hepatic stellate cells (IC50 = 186.34 µM). Zeaxanthin (25 mg/kg) reduces hepatic collagen deposition and levels of thiobarbituric acid reactive substances (TBARS), as...

Isobutyryl-L-carnitine is a natural 4-carbon acylcarnitine that is involved in fatty acid oxidation and organic acid metabolism. Elevated levels of isobutyryl-L-carnitine are associated with isobutyryl-CoA dehydrogenase deficiency.Formal Name: (2R)-3-carboxy-N,N,N-trimethyl-2-(2-methyl-1-oxopropoxy)-1-propanaminium,...

A common metabolic pathway for several prostaglandins (PGs), including prostaglandin D2 (PGD2), involves the reduction of the double bond between C-13 and C-14 and oxidation of the hydroxyl group at C-15, producing 13,14-dihydro-15-keto PGs. The removal of four carbons at the alpha-terminus and oxidation of the...

Mouse double minute 2 protein (MDM2) is an E3 ubiquitin-protein ligase that binds and ubiquitinates the tumor suppressor p53, leading to its degradation by the proteasome. SP-141 is a cell-permeable inhibitor of MDM2 (Ki = 28 nM). Binding of MDM2 by SP-141 promotes its auto-ubiquitination and proteasomal...

Caveolin-1 (82-101) amide is a 20-amino acid synthetic peptide fragment corresponding to residues 82-101 of caveolin-1, which is involved in endocytosis and interacts with a variety of receptors and other proteins. Caveolin-1 (82-101) (0.8 µmol/kg) reduces aging-induced increases in microvascular leakage and...