Anti-Caspase-8 (Clone 90A992)

Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation, and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into an a2b2 tetramer to form the active enzyme. Caspase-8 (FLICE) forms a direct link between the activation of CD95 and the caspase pathway. Overexpression of caspase-8 induces apoptosis, which can be blocked by inhibitors specific for the ICE family.Immunogen: human caspase-8 amino acids PVETDSEEQP. Clone Designation: 90A992. Formulation: (Request formulation change), 100 µg Protein G purified IgG1 in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Host: Mouse. Isotype: IgG1. Applications: FC, IHC (paraffin-embedded tissue), and WB.