CINPA1 is a constitutive androstane receptor (CAR) antagonist (IC50 = 70 nM in a reporter assay). It is selective for CAR over the nuclear receptors GR, FXR, LXRalpha, LXRbeta, PPARgamma, RXRalpha, and RXRbeta at 18 µM, but also antagonizes the human pregnane X receptor (PXR, IC50 = 6.6 µM). CINPA1 (0.3-5 µM)...

Bz-RS-ISer(3-Ph)-OMe is an intermediate in the synthesis of 7-epi-10-deacetyltaxol (Cay-34296), a taxane diterpenoid with alpha-glucosidase inhibitory and anticancer activities.Formal Name: betaS-(benzoylamino)-alphaR-hydroxy-benzenepropanoic acid, methyl ester. CAS Number: 32981-85-4. Molecular Formula: C17H17NO4....

Senexin A is an inhibitor of cyclin-dependent kinase 8 (Cdk8, IC50 = 0.28 µM). It also inhibits cyclin-dependent kinase inhibitor p21WAF1-induced reporter expression in reporter assay using HT-1080 p21-9 cells (IC50 = 0.68 µM). Senexin A (2.5 µM) prevents 17beta-estradiol-induced increases in expression of mRNA...

alpha-Muricholic acid is a murine-specific primary bile acid. Dietary administration of soybean protein decreases fecal levels of alpha-muricholic acid in mice with high-fat diet-induced obesity which correlates with increases in fecal Clostridium cluster XIVa, a major producer of secondary bile acids. Plasma,...