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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
200-401-G91 | 100 µg | - | - |
6 - 10 business days* |
684.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Anti-CXCR4 Antibody was DEAE purified. A BLAST analysis was used to suggest cross-reactivity with... more
Product information "Anti-CXCR4"
Anti-CXCR4 Antibody was DEAE purified. A BLAST analysis was used to suggest cross-reactivity with CXCR4 with Human and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with CXCR4 from other sources has not been determined. No reaction to the 84 kDa STAT1a. CXCR4 antibody detects a G coupled -protein receptor. Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The a-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites. Anti-CXCR4 antibodies are ideal for investigators involved in Cytokines and Growth Factors or Infectious Disease reasearch.
Keywords: | Anti-HM89, Anti-LCR1, Anti-FB22, Anti-CXCR4, Anti-CD184, Anti-NPYRL, Anti-LESTR, Anti-Fusin, Anti-CXC-R4, Anti-CXCR-4, Anti-SDF-1 receptor, Anti-C-X-C chemokine receptor type 4, Anti-Stromal cell-derived factor 1 receptor |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 200-401-G91 |
Properties
Application: | FC, IHC, IFM, IP, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | peptide corresponding to amino acids near the n-terminus of human CXCR4. |
Format: | Purified |
Database Information
KEGG ID : | K04189 | Matching products |
UniProt ID : | P61073 | Matching products |
Gene ID | GeneID 7852 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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