Anti-CD74 (Clone PIN1)

Anti-CD74 (Clone PIN1)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10011432-25 25 µg -

6 - 10 business days*

158.00€
Cay10011432-100 100 µg -

6 - 10 business days*

526.00€
 
CD74 is a non-polymorphic type II integral membrane protein. It has a short N-terminal... more
Product information "Anti-CD74 (Clone PIN1)"
CD74 is a non-polymorphic type II integral membrane protein. It has a short N-terminal cytoplasmic tail of 28 amino acids, followed by a single 24 amino acid transmembrane region and an approximately 150 amino acid lumenal domain. The CD74 chain is thought to function mainly as a major histocompatibility complex (MHC) class II chaperone, which promotes endoplasmic reticulum (ER) exit of MHC class II molecules, directs them to endocytic compartments, prevents peptide binding in the ER, and contributes to peptide editing in the MHC class II compartment. Class II MHC and invariant chain expression was believed to be restricted to classical antigen-presenting cells (APC), however, during inflammation, other cell types, including mucosal epithelial cells, have also been reported to express class II MHC molecules. Experiments that investigate cell-surface CD74 are complicated by the fact that CD74 remains on the cell surface for a very short time. The surface half-life of CD74 was calculated to be fewer than 10 minutes. CD74 however has also recently been shown to have a role as an accessory-signalling molecule because of its macrophage migration-inhibitory factor (MIF). The restricted expression of CD74 by normal tissues and its very rapid internalization make CD74 an attractive therapeutic target for both cancer and immunologic diseases. Cayman's CD74 Monoclonal Antibody (Clone PIN1) can be used for flow cytometry (FC), immunohistochemistry (IHC), immunocytochemistry (ICC), immunofluorescence (IF), immunoprecipitation (IP), and Western blot (WB) applications.Formula Weight: 33.0. Immunogen: Human CD74 invariant chain synthetic peptide. Clone Designation: PIN.1. Formulation: (Request formulation change), 25 or 100 µg of protein G-affinity purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.09% sodium azide. Host: Mouse. Isotype: IgG1. Applications: FC, IHC, ICC, IF, IP, WB. Cross Reactivity: (+) Human CD74. Origin: Animal/Mouse.
Keywords: Anti-Ii, Anti-p33, Anti-CD74, Anti-DHLAG, Anti-Ia antigen-associated invariant chain, Anti-HLA-DR antigens-associated invariant chain, Anti-HLA class II histocompatibility antigen gamma chain
Supplier: Cayman Chemical
Supplier-Nr: 10011432

Properties

Application: WB, IP, ICC, FC
Antibody Type: Monoclonal
Clone: PIN1
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: purified recombinant CD74 protein
MW: 33 D
Format: Solution

Database Information

KEGG ID : K06505 | Matching products
UniProt ID : P04233 | Matching products

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H316, H319
P Phrases: P264, P280, P305+351+338, P332+313, P337+313
Caution
Our products are for laboratory research use only: Not for administration to humans!
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