Anti-CD4 (Clone RIV7)

Anti-CD4 (Clone RIV7)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10004599-1 1 each -

6 - 10 business days*

422.00€
 
CD4 is a type I transmembrane glycoprotein that functions as a T cell receptor (TCR) co-receptor.... more
Product information "Anti-CD4 (Clone RIV7)"
CD4 is a type I transmembrane glycoprotein that functions as a T cell receptor (TCR) co-receptor. It exists as a single polypeptide chain composed of four extracellular immunoglobulin-like (Ig-like) domains that interact with MHC class II molecules, a transmembrane domain, and a cytoplasmic tail that associates with the tyrosine kinase LCK and mediates signal transduction to the TCR, which is essential for T cell activation. It is expressed on the surface of, and used as a marker for, T cells, and its expression is used to characterize the development stage of thymocytes. Upon binding to antigen-displaying MHC class II molecules expressed by antigen-presenting cells (APCs), naïve CD4+ T cells differentiate and proliferate in a cytokine-dependent manner into a variety of T helper (Th) cell subsets, including Th1, Th2, and Th17 cells, which enhance and direct innate and adaptive immune cell responses to numerous pathogens and have additional roles in cancer, asthma and allergy, and autoimmunity. CD4 is also the receptor for HIV attachment and entry into cells, resulting in depletion of CD4+ cells in patients infected with HIV. Cayman's CD4 Monoclonal Antibody (Clone RVI7) can be used for flow cytometry (FC), immunocytochemistry (ICC), and immunohistochemistry (IHC) applications.Synonyms: Cell Surface Glycoprotein CD4, Cluster of Differentiation 4, T Cell Surface Antigen T4. Immunogen: Human peripheral lymphocytes. Clone Designation: RIV7. Formulation: (Request formulation change), 100 µg of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 0.02% sodium azide. Host: Mouse. Isotype: IgG2a. Applications: FC, ICC, IHC (frozen). Cross Reactivity: (+) CD4. UniProt Accession #: P01730. Origin: Animal/Mouse.
Keywords: Anti-CD4, Anti-CD4, Anti-CD4, Anti-T-cell surface glycoprotein CD4, Anti-T-cell surface antigen T4/Leu-3, Anti-T-cell surface glycoprotein CD4, Anti-T-cell surface antigen T4/Leu-3
Supplier: Cayman Chemical
Supplier-Nr: 10004599

Properties

Application: FC, ICC, IHC (frozen)
Antibody Type: Monoclonal
Clone: RIV7
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Human peripheral lymphocytes
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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