Anti-CD39 (Ectonucleoside Triphosphate Diphosphohydrolase 1, NTPDase 1, Ecto-ATP Diphosphohydrolase

Human CD39 is an integral membrane protein with two transmembrane domains and exists as a homotetramer. Expression of CD39 is found on activated lymphocytes, and also on a subset of T cells, B cells and dendritic cells with weak staining on monocytes and granulocytes. Recently, CD39 and CD73 have been found on regulatory T cells specifically the effector/memory like T cells. CD39 can hydrolyze both nucleoside triphosphates and diphosphates. CD39 is the dominant ecto nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type 2 purinergic (P2) G protein coupled receptors (GPCRs). CD39 has intrinsic ecto-ATPase activity. Expression of CD39 is induced on T cells and increased on B cells as a late activation antigen. The A1 antibody binds to the human CD39 cell surface antigen and has been shown to block MHC independent target cell recognition by hapten-specific CTL. Applications: Suitable for use in Flow Cytometry, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.