Anti-CD34 FITC (Clone ICO-115)

CD34 is a transmembrane phosphoglycoprotein and sialomucin protein that is commonly used as a marker for hematopoietic progenitor cells. It is composed of an N-terminal signaling peptide, a sialylated and O-glycosylated extracellular mucin domain, a cysteine-containing globular domain, a juxtamembrane stalk region, and an intracellular C-terminal tail. CD34 is expressed primarily in hematopoietic progenitor cells but is also expressed in mesenchymal stromal, muscle satellite, interstitial, epithelial and vascular endothelial progenitor, and adipose mesenchymal stem/stromal cells. It has both pro- and anti-adhesion activities, providing an anchor for L-selectin-mediated attachment of lymphocytes in vascular endothelial cells and blocking adhesion of bone marrow-derived mast cells in vitro. CD34 has commonly been used as a marker for the selection and enrichment of hematopoietic stem cells for bone marrow transplants. Cayman's CD34 Monoclonal FITC Antibody (Clone ICO-115) can be used for flow cytometry (FC) and immunofluorescence (IF) applications.Synonyms: Hematopoietic Progenitor Cell Antigen CD34. Clone Designation: ICO-115. Formulation: (Request formulation change), 500 µg of ammonium sulfate-purified, fluorescein labeled monoclonal antibody. Storage Buffer: PBS, pH 7.2. Host: Mouse. Isotype: IgG1. Applications: FC, IF. Cross Reactivity: (+) CD34. UniProt Accession #: P28906. Origin: Animal/Mouse.