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Anti-Bromodomain Adjacent to Zinc Finger Domain 1B (BAZ1

ART NR.: B2852-40.50 (50 µg)

Hersteller: USBio

Datenblatt

Anwendungen: WB

Format: affinity purified

Klon: 8C41

Wirt: Mouse

Isotyp: IgG1

Reaktivität: human

Immunogen: Recombinant hum

Lagerung: -20°C

Versand: +4°C

UniProt ID: Q9UIG0
Suche mit UniProt ID

Geninformationen: GeneID 9031

Schlagworte: EC=2.7.10.2, Anti-hWALp2, Anti-WBSC10, Anti-Tyrosine-protein kinase BAZ1B, Anti-Williams syndrome transcription factor, Anti-Williams-Beuren syndrome chromosomal region 9 protein, Anti-Bromodomain adjacent to zinc finger domain protein 1B

B2852-40.50

50 µg

345 €

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Bemerkungen: Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. In the WINAC complex, plays an essential role by targeting the complex to acetylated histones, an essential step for VDR-promoter association. [The UniProt Consortium]

Spezifikationen

usbio_datasheet_parse.php?nr=B2852-40.50&ak=1
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