Anti-Bim/BOD (IN)

Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of ~23, 16, and 13 kDa, respectively. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse, and rat. Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines. Cayman's Bim/BOD (IN) Polyclonal Antibody can be used for Immunohistochemistry (IHC) and Western blot (WB) applications.Formula Weight: 23.0. Immunogen: Internal central human Bim amino acids. Formulation: (Request formulation change), 25 or 100 µg of protein A-affinity purified monoclonal. Storage Buffer: PBS, pH 7.4, with 50% glycerol and 0.09% sodium azide. Host: Rabbit. Applications: WB, IHC. Origin: Animal/Rabbit.