103 products were found matching "A2275-86E"!

Anti-human APP770 was raised using a synthetic 15-aa peptide near the extracellular, KPI-region (301-316 aa) of human APP770 (1). Peptide was conjugated to KLH. Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognition in the elderly. One of the most important...

Sequence: , DAEFRHDSGY , Location: Amino acids 653 to 662 of human APP (1) , Applications: The peptide is used for blocking the activity of anti-APP. Incubating the peptide with equal volume of antibody for 30 min at 37¡C usually completely blocks the antibody activity in Western blotting. Storage and Stability:...

There are 3 known b-APP proteins (b-APP695, b-APP751, b-APP770). The amyloid b-peptide is thought to be derived from all three precursor proteins. Evidence indicates that b-APP is present in senile plaques, extraneuronal tangles, neurous, satellite glial cells of the dorsal root, enteric and trigerminal ganglia,...

The protein encoded by this gene is a glycoprotein, belonging to the pentaxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the...

APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid...

APPBP1 binds to the beta-amyloid precursor protein, a cell surface protein with signal-transducing properties thought to play a role in the pathogenesis of Alzheimer's disease. In addition, this protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. APPB1 is required for...

Sequence (linear): Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala, Storage and Stability: Lyophilized powder may be stored at -20°C Stable for 12 months at -20°C. Reconstitute (see reconstitution...

Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. In disease state oligomerization, extensive amyloid oligomerization creates plaques in neural tissue that...

A naturally occurring neurotoxin produced by hoplonemertine sea worms competes with the natural neurotransmitter acetylcholine when binding to nicotinic receptor sites. , Solubility: Chloroform , Storage and Stability:, May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum...

Solubility: , Chloroform, Method for Determining Identity: Proton NMR Spectroscopic Analysis and Mass Spectrometric analysis, TLC Conditions: SiO2: Dichloromethane: Methanol: Ammonium Hydroxide, 8ml, 2ml: 5 drops, Visualized with UV, Single spot, Rf=0.5, Storage and Stability: May be stored at RT for short-term...

Amyloid A, Serum, Human (Serum, Amyloid A, SAA) BioAssay(TM) ELISA Kit is to be used for the in vitro quantitative determination human serum amyloid A (SAA) concentrations in serum, plasma, cell culture supernatant and other biological fluids. Amyloidosis includes a family of diseases which have in common the...

Amyloid Precursor Protein (APP) is an integral membrane protein with a large ectodomain, a transmembrane domain, and a short cytoplasmic tail. APP is proteolytically cleaved by b-secretase (BACE) to generate the APP N-terminal fragment (sbAPP) with Mr100kD and a C-terminal fragment (C99) with Mr12kD. The smaller...