Anti-ATR

Anti-ATR
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A300-137A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A300-137A 100 µl (100 µg) -

2 - 8 business days*

588.00€
 
Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon... more
Product information "Anti-ATR"
Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. [The UniProt Consortium]
Keywords: Anti-ATR, Anti-FRP1, EC=2.7.11.1, Anti-FRAP-related protein 1, Anti-Serine/threonine-protein kinase ATR, Anti-Ataxia telangiectasia and Rad3-related protein
Supplier: Bethyl Laboratories
Supplier-Nr: A300-137A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: orangutan, rhesus monkey, gorilla, chimpanzee, crab-eating macaque, northern white-cheeked gibbon)
Immunogen: synthetic peptide. The epitope recognized by A300-137A maps to a region between residues 400 and 450 of human Ataxia Telangiectasia and Rad3-related using the numbering given in entry NP_001175.1 (GeneID 545).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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