20 products were found matching "BPS-25206"!

5 hydroxymethylcytosine (5 hmC) results from the enzymatic conversion of 5 methylcytosine into 5 hydroxymethylcytosine by the TET family of iron dependent oxygenases. 5 hmC bases were recently discovered in mammalian DNA, in Purkinje neurons, in granule cells and embryonic stem cells where theyare present at high...

The 5 methylcytosine antibody (clone 33D3) is the most published and widely used antibody for DNA methylation analysis. It has been validated for Methylated DNA Immunoprecipitation (MeDIP seq, MeDIP on chip), Immunofluorescence, Flow Cytometry, Dot blot & ELISA.

The AML1 (RUNX1) (UniProtKB/Swiss-Prot entry Q01196) - ETO (RUNX1T1) (UniProtKB/Swiss-Prot entry Q06455) fusion protein arises due to a translocation between chromosome 8 and 22 (t(8,21)(q22,q22)). This translocation is one of the most frequent karyotypic abnormalities observed in acute myeloid leukaemia. It...

ASH2 (UniProtKB/Swiss Prot entry Q9UBL3) is a component of the SET1/ASH2 histone methyltransferase (HMT) complex. This complex specifically methylates K4 of histone H3, thereby activating transcription. Methylation of K4 is blocked by premethylation of the neighboring K9, a repressor of transcription. This indicates...

5 hydroxymethylcytosine (5 hmC) results from the enzymatic conversion of 5 methylcytosine into 5 hydroxymethylcytosine by the TET family of iron dependent oxygenases. 5 hmC bases were recently discovered in mammalian DNA, in Purkinje neurons, in granule cells and embryonic stem cells where theyare present at high...

The so-called 6th base, 5 hydroxymethylcytosine has been discovered in 2009. The function of this new modified base remains mostly unclear, but it is certain that the 5 hmC base is generated by enzymatic conversion of 5 methylcytosine(5 mC) into 5 hydroxymethylcytosine by the TET family of oxygenases. Early reports...

3 methylcytosine arises by erroneous methylation of DNA through spontaneous exposure to endogenous S adenosyl methionine (SAM). Since the N3 position in cytosine is protected in double stranded DNA, this phenomenon mainly occurs in single stranded DNA. The resulting 3 mC is toxic and mutagenic and increased levels...

5 hydroxymethylcytosine (5 hmC) results from the enzymatic conversion of 5 methylcytosine into 5 hydroxymethylcytosine by the TET family of iron dependent oxygenases. 5 hmC bases were recently discovered in mammalian DNA, in Purkinje neurons, in granule cells and embryonic stem cells where theyare present at high...

Trimethylation of H3K64 (H3K64me3)has been identiefied as a modification that is enriched at pericentric heterochromatin and associated with repeat sequences and transcriptionally inactive genomic regions.

Human Histone B, GenBank Accession No. NM_003528, a.a. 2-126(end) with N-terminal His-tag, MW = 14.6 kDa, expressed in an E. coli expression system.

Affinity purified Anti-ERK1/2, clone E31R, mouse IgG1. Recognizes human ERK1 and ERK2 proteins. Application: Western blotting (1:1000). Optimal dilutions/concentrations should be determined by the end user. Predicted molecular weight: 41, 43 kDa.

DNMT1 (UniProt/Swiss Prot entry P26358) preferentially methylates CpG residues in hemimethylated DNA and is responsible for maintaining methylation patterns established in development. Inactivation of DNMT1 causes global demethylation and embryonic lethality. DNA methylation is coordinated with methylation of...