20 products were found matching "BPS-25204"!

5 hydroxymethylcytosine (5 hmC) results from the enzymatic conversion of 5 methylcytosine into 5 hydroxymethylcytosine by the TET family of iron dependent oxygenases. 5 hmC bases were recently discovered in mammalian DNA, in Purkinje neurons, in granule cells and embryonic stem cells where theyare present at high...

The 5 methylcytosine antibody (clone 33D3) is the most published and widely used antibody for DNA methylation analysis. It has been validated for Methylated DNA Immunoprecipitation (MeDIP seq, MeDIP on chip), Immunofluorescence, Flow Cytometry, Dot blot & ELISA.

The AML1 (RUNX1) (UniProtKB/Swiss-Prot entry Q01196) - ETO (RUNX1T1) (UniProtKB/Swiss-Prot entry Q06455) fusion protein arises due to a translocation between chromosome 8 and 22 (t(8,21)(q22,q22)). This translocation is one of the most frequent karyotypic abnormalities observed in acute myeloid leukaemia. It...

ASH2 (UniProtKB/Swiss Prot entry Q9UBL3) is a component of the SET1/ASH2 histone methyltransferase (HMT) complex. This complex specifically methylates K4 of histone H3, thereby activating transcription. Methylation of K4 is blocked by premethylation of the neighboring K9, a repressor of transcription. This indicates...

5 hydroxymethylcytosine (5 hmC) results from the enzymatic conversion of 5 methylcytosine into 5 hydroxymethylcytosine by the TET family of iron dependent oxygenases. 5 hmC bases were recently discovered in mammalian DNA, in Purkinje neurons, in granule cells and embryonic stem cells where theyare present at high...

The so-called 6th base, 5 hydroxymethylcytosine has been discovered in 2009. The function of this new modified base remains mostly unclear, but it is certain that the 5 hmC base is generated by enzymatic conversion of 5 methylcytosine(5 mC) into 5 hydroxymethylcytosine by the TET family of oxygenases. Early reports...

3 methylcytosine arises by erroneous methylation of DNA through spontaneous exposure to endogenous S adenosyl methionine (SAM). Since the N3 position in cytosine is protected in double stranded DNA, this phenomenon mainly occurs in single stranded DNA. The resulting 3 mC is toxic and mutagenic and increased levels...

5 hydroxymethylcytosine (5 hmC) results from the enzymatic conversion of 5 methylcytosine into 5 hydroxymethylcytosine by the TET family of iron dependent oxygenases. 5 hmC bases were recently discovered in mammalian DNA, in Purkinje neurons, in granule cells and embryonic stem cells where theyare present at high...

Methylation at Lys-9 (H3K9me) and Lys-27 (H3K27me) are linked to gene repression. Lysine 27 of histone H3 can be mono-, di- or trimethylated (Histone H3 monomethyl Lys27, Histone H3 dimethyl Lys27 or Histone H3 trimethyl Lys27) by different histone methyltransferases such as EZH2 or NSD3. Methylation of this residue...

Human Histone 4 (HIST2H4A) (GenBank Accession No. NM_003548), a.a. 2-104(end) with N-terminal His-tag, MW = 12.1 kDa, expressed in an E. coli expression system. A suitable substrate for histone methyltransferases.

Lysine 4 of histone H3 can be mono-, di- or trimethylated by different histone methyltransferases (HMTs) such as SET1 or ASH1. Methylation of Lys4 is often associated with transcriptional activation. The demethylase LSD1 is able to demethylate histone H3 Lys4. Asymmetric dimethylation at Arg2 (H3R2me2a) by PRMT6 is...

Affinity purified monoclonal Anti-ERK1, clone E19, mouse, IgG1. Recognizes only the ERK1 protein. Detects a band of approximately 43 kDa. Applications: Western Blotting (1:1000-10000), Immunoprecipitation. Optimal dilutions/concentrations should be determined by the end user.