Anti-5 hmC (mouse)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
BPS-25202 50 µg - -

3 - 15 business days*

873.00€
 
5 hydroxymethylcytosine (5 hmC) results from the enzymatic conversion of 5 methylcytosine into 5... more
Product information "Anti-5 hmC (mouse)"
5 hydroxymethylcytosine (5 hmC) results from the enzymatic conversion of 5 methylcytosine into 5 hydroxymethylcytosine by the TET family of iron dependent oxygenases. 5 hmC bases were recently discovered in mammalian DNA, in Purkinje neurons, in granule cells and embryonic stem cells where theyare present at high levels (up to 0.6% of total nucleotides in Purkinje cells). Recent reports indicate that 5 hmC is abundant in brain tissue, especially in areas that are associated with higher cognitive functions. Preliminary results indicate that 5 hmC may have important roles distinct from 5 mC. Although its precise role has still to be shown, early evidence suggests 5 hydroxymethylcytosine may represent a new and unique pathway to demethylate DNA involving a repair mechanism converting 5 hmC to cytosine. Due to the structural similarity between 5 mC and 5 hmC, these bases are experimentally almost indistinguishable. The most commonly used methodologies (e.g. enzymatic approaches, bisulfite sequencing) do not distinguish 5mc from 5 hmC. The development of specific antibodies appears to be the most powerful way to distinguish and specifically enrich for 5 mC and 5 hmC sequences.
Keywords: Anti-5 hydroxymethylcytosine, Anti-5-hydroxymethyl-cytosine
Supplier: BPS Bioscience
Supplier-Nr: 25202

Properties

Application: hMeDIP, Dot Blot, ELISA, IF
Antibody Type: Monoclonal
Conjugate: No
Immunogen: 5 hydroxymethylcytosine conjugated to BSA
Format: Purified

Database Information

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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