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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
BPS-25202 | 50 µg | - | - |
3 - 15 business days* |
873.00€
|
5 hydroxymethylcytosine (5 hmC) results from the enzymatic conversion of 5 methylcytosine into 5... more
Product information "Anti-5 hmC (mouse)"
5 hydroxymethylcytosine (5 hmC) results from the enzymatic conversion of 5 methylcytosine into 5 hydroxymethylcytosine by the TET family of iron dependent oxygenases. 5 hmC bases were recently discovered in mammalian DNA, in Purkinje neurons, in granule cells and embryonic stem cells where theyare present at high levels (up to 0.6% of total nucleotides in Purkinje cells). Recent reports indicate that 5 hmC is abundant in brain tissue, especially in areas that are associated with higher cognitive functions. Preliminary results indicate that 5 hmC may have important roles distinct from 5 mC. Although its precise role has still to be shown, early evidence suggests 5 hydroxymethylcytosine may represent a new and unique pathway to demethylate DNA involving a repair mechanism converting 5 hmC to cytosine. Due to the structural similarity between 5 mC and 5 hmC, these bases are experimentally almost indistinguishable. The most commonly used methodologies (e.g. enzymatic approaches, bisulfite sequencing) do not distinguish 5mc from 5 hmC. The development of specific antibodies appears to be the most powerful way to distinguish and specifically enrich for 5 mC and 5 hmC sequences.
Keywords: | Anti-5 hydroxymethylcytosine, Anti-5-hydroxymethyl-cytosine |
Supplier: | BPS Bioscience |
Supplier-Nr: | 25202 |
Properties
Application: | hMeDIP, Dot Blot, ELISA, IF |
Antibody Type: | Monoclonal |
Conjugate: | No |
Immunogen: | 5 hydroxymethylcytosine conjugated to BSA |
Format: | Purified |
Database Information
Handling & Safety
Storage: | -80°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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