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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
N7100-71F.100 | 100 tests | - | - |
3 - 19 business days* |
808.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD73 (also known as [ecto]-5'-nucleotidase/5'-NT) is a variably glycosylated, 69-73kD member of... more
Product information "Anti-5'-Nucleotidase (CD73, CD73 Antigen, Ecto-5'nucleotidase, 5'-NT, eN, eNT, NT5, NT5E, NTE, Purin"
CD73 (also known as [ecto]-5'-nucleotidase/5'-NT) is a variably glycosylated, 69-73kD member of the 5'-nucleotidase family of enzymes. It is expressed on multiple cell types, including vascular endothelium, transitional and nonkeratinized epithelium, cardiomyocytes, small intestine epithelium, FoxP3 Treg lymphocytes, FDCs, and B cells. CD73 hydrolyzes AMP to adenosine and phosphate. This creates diffusible nucleosides necessary for cell homeostasis, and a ligand for cell membrane adenosine receptors. Mature human CD73 is a 523aa GPI-linked protein (aa27-549). It contains a large Zn-dependent nucleotidase catalytic region (aa28-532) and a C-terminal substrate binding site (aa500-506). On the cell surface, it exists as a disulfide-linked homodimer. Two splice variants are reported. One shows a deletion of aa405-454, and a second possesses a 12aa substitution for aa253-574. Over aa1-511, human CD73 shares 88% aa identity with both mouse and rat CD73. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 10ul/10e6 cells using human peripheral blood mononuclear cells, Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Keywords: | EC=3.1.3.5, Anti-5'-nucleotidase, Anti-Ecto-5'-nucleotidase |
Supplier: | United States Biological |
Supplier-Nr: | N7100-71F |
Properties
Application: | FC |
Antibody Type: | Monoclonal |
Clone: | 10K16 |
Conjugate: | Phycoerythrin |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | CHO-derived, recombinant human 5? Nucleotidase/CD73 (aa1-511, Accession #AAH65937). |
Format: | Affinity Purified |
Database Information
KEGG ID : | K19970 | Matching products |
UniProt ID : | P21589 | Matching products |
Gene ID | GeneID 4907 | Matching products |
Handling & Safety
Storage: | +4°C (do not freeze) |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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