Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context.
Cat-Nr: AG-40A-0016-C050
Menge: 50 µg
Preis: 693 €
UniProt ID: O15124 (Protein knowledgebase)
Schlagworte:
ANG-2, ANG2, ANGPT2
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![Info: ANGPTLs [Angiopoietin-like Proteins]](dateien/infos_nr1260_preview.gif "Info: ANGPTLs [Angiopoietin-like Proteins]")
