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Angiopoietin-1 (human, rec.)

ART NR.: AG-40A-0014-C010 (10 µg)
AG-40A-0014-C050 (50 µg)

Hersteller: Adipogen

Datenblatt

Anwendungen: Bioassays

MW: 57 kD

Format: liquid

UniProt ID: Q15389
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Schlagworte: Ang-1, Ang1, Angpt1

10 µg

231 €

50 µg

693 €

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Bemerkungen: Human angiopoietin-1 (amino acids 20-498) is fused at the N-terminus to a FLAG(R)-tag. Induces phosphorylation of Tie-2 in primary cultured human vascular endothelial cells (HUVECs). The protein forms mainly tetrameric structures. Liquid. 0.2µm-filtered solution in PBS containing 0.02% CHAPS. Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context.
Image Art AG-40A-0014-C010 Adipogen Angiopoietin-1 (human, rec.)
Figure legend: Datenblatt ansehen

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