Human angiopoietin-1 (amino acids 20-498) is fused at the N-terminus to a FLAG(R)-tag. Induces phosphorylation of Tie-2 in primary cultured human vascular endothelial cells (HUVECs). The protein forms mainly tetrameric structures. Liquid. 0.2µm-filtered solution in PBS containing 0.02% CHAPS. Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context.
Menge: 10 µg
Preis: 231 €
UniProt ID: Q15389 (Protein knowledgebase)
Ang-1, Ang1, Angpt1
Figure legend: Datenblatt ansehen
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Products for: ANGPT1 - angiopoietin 1