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Angiopoietin-​1 (human, rec.)

MW: 57 kD

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E.coli human
Erklärungen der Abkürzungen ansehen.
liquid BioassaysErklärungen der Abkürzungen ansehen. Adipogen
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AG-​40A-​0014-​C010 10 µg

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Human angiopoietin-​1 (amino acids 20-​498) is fused at the N-​terminus to a FLAG(R)-​tag. Induces phosphorylation of Tie-​2 in primary cultured human vascular endothelial cells (HUVECs). The protein forms mainly tetrameric structures. Liquid. 0.2µm-​filtered solution in PBS containing 0.02% CHAPS. Angiopoietin-​1 (Ang-​1) and angiopoietin-​2 (Ang-​2) are closely related secreted ligands which bind with similar affinity to Tie-​2. Tie-​2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-​1 activates Tie-​2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-​2 has been identified as a secreted protein ligand of Tie-​2 and has alternatively been reported to be an antagonist for Ang-​1 induced Tie-​2 signaling as well as an agonist for Tie-​2 signaling, depending on the cell context.
Cat-Nr:
AG-40A-0014-C010
Menge:
10 µg
Preis:
231 €

UniProt ID: Q15389 (Protein knowledgebase)

Schlagworte:
Ang-​1, Ang1, Angpt1
Image Art AG-40A-0014 Adipogen Angiopoietin-​1 (human, rec.)
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