6 products were found matching "Cay14181"!

Amlexanox is an anti-inflammatory and anti-allergic compound which is useful in the amelioration of aphthous ulcers (canker sores), commonly used as a 5% topical oral paste. By way of mechanism of action, amlexanox associates with the calcium-binding proteins S100A12 and S100A13, inhibits the release of FGF1, and,...

Caffeine is a methylxanthine alkaloid naturally found in various plant parts that acts as an antagonist at central adenosine receptors at relevant physiological concentrations (IC50 = ~30 µM). It alters fatigue, mood, alertness, motor reaction time, vascular hemodynamics, and pain sensation. Caffeine has also been...

Chrysomycin A is an antibiotic isolated from a strain of Streptomyces. It is structurally very similar to gilvocarcin V, an inhibitor of topoisomerase II which promotes DNA cross-linking with histone 3 and GRP78 when photoactivated by near-UV light. Chrysomycin A inhibits DNA synthesis in bacteria and suppresses the...

D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G1 to the S phase. Cell cycle deregulation in many cancers often results from altered cyclin D/CDK activity. S14161 is a...

Chrysomycin B is an antibiotic isolated from a strain of Streptomyces. It differs from its analog chrysomycin A (Cay-14188) by having a methyl, rather than vinyl, group in the 8-position of the chromophore. Like its analog, chrysomycin B suppresses the growth of transplantable tumors in mice, an effect that may be...

The human aldose reductase AKR1B1 is considered the rate limiting enzyme of the polyol pathway responsible for the conversion of glucose into sorbitol. It also acts as a highly efficient PGF2alpha synthase in response to interleukin-1beta. Increased aldose reductase expression has been associated with complications...