- Search results for Cay15881
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8 products were found matching "Cay15881"!
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Item number: Cay15881-5
Amitriptyline is a first generation tricyclic antidepressant. It inhibits serotonin (5-HT) uptake by isolated human platelets by 39 and 68% when used at concentrations of 1 and 4 µg/ml, respectively, and inhibits norepinephrine uptake in rat brain by 77% when administered at a dose of 10 mg/kg. It is also an...
Keywords: | NIH 10794, Ro 4-1575, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine, monohydrochloride |
Application: | Serotonin / noradrenalin transporter inhibitor |
CAS | 549-18-8 |
MW: | 313.9 D |
From 43.00€
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Item number: Cay15558-1
Ramipril is a prodrug form of the angiotensin-converting enzyme (ACE) inhibitor ramiprilat (Cay-15557). Ramipril (2.5 mg/kg per day, p.o.) reduces systolic blood pressure in spontaneously hypertensive rats. It reduces aortic valve backscatter and improves aortic flow in a rabbit model of aortic valve stenosis....
Keywords: | HOE 498,... |
Application: | Angiotensin-converting enzyme (ACE) inhibitor |
CAS | 87333-19-5 |
MW: | 416.5 D |
From 84.00€
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Item number: Cay15588-1
Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 µM, respectively. Ganglioside GT1b-containing...
Keywords: | Ganglioside G1 Mixture |
Application: | Trisialoganglioside |
MW: | 2126.3 D |
From 145.00€
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Item number: Cay11588-1
AZD 8330 is a selective allosteric inhibitor of MEK1/2 (IC50 = 7 nM). It blocks phosphorylation of ERK1/2 and inhibits proliferation of certain cancer cells. AZD 8330 is orally bioavailable, inhibits ERK phosphorylation in vivo, and reduces tumor growth in a Calu-6 nude rat xenograft model.Formal Name:...
Keywords: | ARRY-424704, 2-[(2-fluoro-4-iodophenyl)amino]-1,6-dihydro-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-3-pyridinecarboxamide |
Application: | MEK inhibitor |
CAS | 869357-68-6 |
MW: | 461.2 D |
From 84.00€
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Item number: Cay15888-1
Doxepin is a tricyclic antidepressant that binds to the serotonin (5-HT) transporter (SERT) and norepinephrine transporter (NET, Kds = 68 and 29.5 nM, respectively). It is a histamine H1 receptor antagonist (Ki = 1.23 nM). Doxepin selectively binds to SERT and NET over the dopamine transporter (DAT, Kd = 12,100 nM)...
Keywords: | 3-(dibenz[b,e]oxepin-11(6H)-ylidene)-N,N-dimethyl-1-propanamine, monohydrochloride |
Application: | Histamine, serotonin, adrenergic, muscarinic receptor antagonist, Norepinephrine reuptake inhibitor |
CAS | 1229-29-4 |
MW: | 315.8 D |
From 50.00€
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Item number: Cay15581-5
Dexmedetomidine is the (S)-enantiomer of medetomidine, an imidazole compound that binds to alpha2-adrenoceptors (Ki = 1.08 nM) with high affinity and selectivity compared to that of alpha1-adrenoceptors (Ki = 1.8 µM). Dexmedetomidine produces analgesic, sedative, and anxiolytic effects through both presynaptic...
Keywords: | Dex, Precedex, 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, monohydrochloride |
Application: | alpha2-adrenergic receptor agonist |
CAS | 145108-58-3 |
MW: | 236.7 D |
From 66.00€
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Item number: Cay11581-25
5'-Ethynyl-2'-deoxycytidine (EdC) is a nucleoside analog that inhibits replication of the herpes simplex virus-1 (HSV-1) KOS strain (ID50 = 0.2 µg/mL). It also reduces virus-induced cytopathogenicity of HSV-1, HSV-2, and vaccinia virus strains in PRK cells (MICs = 0.2-0.4, 1-2, and 5 µg/ml, respectively). EdC is an...
Keywords: | 2'-deoxy-5-Ethynylcytidine, EdC, 2'-deoxy-5-ethynyl-cytidine |
CAS | 69075-47-4 |
MW: | 251.2 D |
From 43.00€
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Item number: Cay15884-1
Clomipramine is a tricyclic antidepressant, the 3-chlorinated derivative of imipramine (Cay-15890). Like imipramine, clomipramine potently inhibits serotonin and norepinephrine reuptake (Kis = 7.4 and 96 nM, respectively). It also is an antagonist at histamine, muscarinic acetylcholine, alpha1-adrenergic, and...
Keywords: | 3-chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine, monohydrochloride |
Application: | Serotonin norepinephrine reuptake inhibitor |
CAS | 17321-77-6 |
MW: | 351.3 D |
50.00€
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