12 products were found matching "Cay15986-25"!

3-CAF is a synthetic cannabinoid featuring a 3-carboxylate-indazole structure with a 1-(2-fluorophenyl) group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.Formal Name: 1-(2-fluorophenyl)-1H-indazole-3-carboxylic acid,...

Paeonol is a phenol that has been found in Paeonia and has diverse biological activities. It inhibits LPS- and IFN-gamma-induced migration and production of reactive oxygen species (ROS) in BV-2 microglia when used at concentrations of 10 and 30 µM. Paeonol inhibits histamine release from rat peritoneal mast cells...

Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 µM, respectively). This inhibition is irreversible. Clorgyline is without effect on serotonin (Cay-14332) receptors, but it does inhibit the sigma receptor sigma1 on Jurkat human T lymphocyte...

5-Cyano-2,3-di-(p-tolyl)tetrazolium (chloride) is a redox-sensitive tetrazolium salt used primarily to detect metabolic activity in microorganisms. This membrane-permeable indicator is readily taken up by living cells and reduced by respiratory activity to produce a red fluorescent, water-insoluble formazan crystal...

Loratadine is a non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM). It has been shown to inhibit the release of leukotriene C4 (IC50 = 8 µM) and histamine (IC50 = 11 µM) from rodent mast cells and to inhibit allergic bronchospasm in guinea pigs with...

Trehalose is a natural non-reducing disaccharide found in plants, invertebrates, fungi, and bacteria. In addition to roles as an energy source and stress protectant, trehalose can function as a signaling molecule. Trehalose 6-phosphate is an intermediate in the biosynthesis of trehalose. It is generated from...

Lactobionic acid is an aldonic acid that is comprised of galactose and gluconic acid and can be produced by the lactose oxidation pathway in Pseudomonas. Lactobionic acid increases the water solubility of clarithromycin and has been used as a low pH buffer for the entrapment of SYK kinase inhibitors in liposomal...

Betaxolol is an antagonist of the beta1-adrenergic receptor (beta1-AR, Ki = 23 nM). It is selective for the beta1-AR over the beta2-AR (Ki = 790 nM). Betaxolol is cytotoxic to 10.014 pRSV-T human corneal epithelial cells. It reduces intraocular pressure in cynomolgus monkeys with ocular hypertension induced by laser...

7-ethoxy-4-Methylcoumarin is a fluorophore that has been used to monitor functional activity of cytochrome P450 (CYP)1A1, CYP2B4, and CYP2B6. It demonstrates excitation/emission maxima of 318 and 377 nm, respectively in methanol and 360 and 449 nm, respectively in dealkylase.Formal Name:...

4-Aminobenzoic acid, commonly known as PABA, is an intermediate in the synthesis of tetrahydrofolic acid (Cay-18263) in many non-mammalian organisms, including bacteria and fungi. Folates, like tetrahydrofolic acid, have critical roles in the metabolism of nucleic acid precursors and several amino acids, as well as...

7-Methylguanosine is a methylated form of the purine nucleoside guanosine (Cay-27702). It is an RNA modification that is present in the 5'-terminal cap of mRNA, where it promotes translation, as well as in tRNA, where it stabilizes the tRNA structure. 7-Methylguanosine has been used as a substrate to measure the...

Metolazone is a thiazide-like diuretic. It inhibits the Na+/Cl- cotransporter (IC50 = 0.3 µM for the rat transporter) and human carbonic anhydrase VII (CAVII), CAXII, and CAXIII (Kis = 2.1, 5.4, and 15 nM, respectively). Metolazone (0.3 and 1 mg/kg) induces fluid loss and enhances captopril-induced decreases in...