13 products were found matching "Cay15986"!

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6beta-Naltrexol
6beta-Naltrexol

Item number: Cay15896-5

6beta-Naltrexol (Cay-15896) is an analytical reference material that is structurally categorized as an opioid. It is the major metabolite of naltrexone (Cay-ISO60192, Cay-15520). Unlike naltrexone, which acts as a µ-receptor antagonist or inverse agonist, 6beta-naltrexol is a neutral opioid antagonist....
Keywords: 6beta-hydroxy Naltrexone, (5alpha,6beta)-17-(cyclopropylmethyl)-4,5-epoxy-morphinan-3,6,14-triol
Application: Analytical reference material, Opioid, Major naltrexone metabolite
CAS 49625-89-0
MW: 343.4 D
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7-ethoxy-4-Methylcoumarin
7-ethoxy-4-Methylcoumarin

Item number: Cay19586-1

7-ethoxy-4-Methylcoumarin is a fluorophore that has been used to monitor functional activity of cytochrome P450 (CYP)1A1, CYP2B4, and CYP2B6. It demonstrates excitation/emission maxima of 318 and 377 nm, respectively in methanol and 360 and 449 nm, respectively in dealkylase.Formal Name:...
Keywords: 4-Methyl-7-Ethoxycoumarin, 4-Methylumbelliferone ethyl ether, NSC 60561, 7-ethoxy-4-methyl-2H-1-benzopyran-2-one
Application: CYP1A1 / CYP2B4 / CYP2B6 activity monitoring, Fluorophore
CAS 87-05-8
MW: 204.2 D
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4-Aminobenzoic Acid (sodium salt)
4-Aminobenzoic Acid (sodium salt)

Item number: Cay18659-50

4-Aminobenzoic acid, commonly known as PABA, is an intermediate in the synthesis of tetrahydrofolic acid (Cay-18263) in many non-mammalian organisms, including bacteria and fungi. Folates, like tetrahydrofolic acid, have critical roles in the metabolism of nucleic acid precursors and several amino acids, as well as...
Keywords: p-Aminobenzoic Acid, PABA, 4-amino-benzoic acid, monosodium salt
Application: Tetrahydrofolic acid synthesis intermediate
CAS 555-06-6
MW: 159.1 D
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Moxalactam (sodium salt)
Moxalactam (sodium salt)

Item number: Cay15869-500

Moxalactam is a beta-lactam antibiotic in the cephalosporin class. It is classified as an oxacephem, as oxygen replaces sulfur in position one of the dihydrothiazolidine ring. While moxalactam inhibits most commonly occurring gram positive, gram negative, and anaerobic bacteria, it is ineffective against...
Keywords: Antibiotic 6059S, Latamoxef, LY 127935,...
Application: beta-lactam antibiotic
CAS 64953-12-4
MW: 564.4 D
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Goat Anti-GST IgG:SureLight(TM) APC
Goat Anti-GST IgG:SureLight(TM) APC

Item number: Cay16598-1

Goat anti-GST (Glutathione-S-Transferase) IgG conjugated to SureLight(TM) APC Antibody: Goat polyclonal anti-GST IgG Dye: SureLight(TM) Allophycocyanin (APC) Excitation max. lambda: 652 nm Emission max. lambda: 657.5 nm Uses: Flow cytometry, Fluorescence-activated cell sorting, Optimized for high-throughput...
Application: FC, Fluorescence, HTS, TR-FRET
Host: Goat
From 488.00€ *
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7-Methylguanosine
7-Methylguanosine

Item number: Cay15988-100

7-Methylguanosine is a methylated form of the purine nucleoside guanosine (Cay-27702). It is an RNA modification that is present in the 5'-terminal cap of mRNA, where it promotes translation, as well as in tRNA, where it stabilizes the tRNA structure. 7-Methylguanosine has been used as a substrate to measure the...
Keywords: 7-methyl-guanosine
Application: 5' terminal cap structure analog, cancer biomarker
CAS 20244-86-4
MW: 297.3 D
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Metolazone
Metolazone

Item number: Cay15987-10

Metolazone is a thiazide-like diuretic. It inhibits the Na+/Cl- cotransporter (IC50 = 0.3 µM for the rat transporter) and human carbonic anhydrase VII (CAVII), CAXII, and CAXIII (Kis = 2.1, 5.4, and 15 nM, respectively). Metolazone (0.3 and 1 mg/kg) induces fluid loss and enhances captopril-induced decreases in...
Keywords: SR 720-22, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
Application: Na+-Cl- symport / SLC12A3 inhibitor
CAS 17560-51-9
MW: 365.8 D
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Lofexidine (hydrochloride)
Lofexidine (hydrochloride)

Item number: Cay15989-500

Lofexidine is an alpha2-adrenergic receptor agonist (Kd = 7.6 nM for rat cerebral cortex membranes) that has transient antihypertensive effects. It is used in managing opioid withdrawal symptoms during detoxification from heroin (Cay-9001543) and methadone.Formal Name:...
Keywords: 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole, monohydrochloride
Application: alpha2b-adrenergic receptor agonist
CAS 21498-08-8
MW: 295.6 D
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Pirfenidone
Pirfenidone

Item number: Cay13986-5

Pirfenidone is an orally bioavailable pyridone derivative with antifibrotic, anti-inflammatory, and antioxidant activities. It inhibits TGF-beta1-stimulated increases in collagen type I, fibronectin, and Hsp47 expression in A549 lung cancer cells in a concentration-dependent manner. Pirfenidone (300 mg/kg per day)...
Keywords: AMR 69, 5-methyl-1-phenyl-2(1H)-pyridinone
Application: Antioxidant, Antiinflammatory
CAS 53179-13-8
MW: 185.2 D
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Ac-DEVD-AMC
Ac-DEVD-AMC

Item number: Cay14986-5

Ac-DEVD-AMC is a fluorogenic substrate that can be cleaved specifically by caspase-3. Caspase activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm.Formal Name:...
Keywords: Caspase-3 Substrate (Fluorogenic), N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-Methylcoumarin,...
Application: Fluorogenic caspase-3 substrate
CAS 169332-61-0
MW: 675.6 D
From 82.00€ *
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BYL719
BYL719

Item number: Cay16986-5

BYL719 is an inhibitor of phosphoinositide 3-kinase alpha (PI3Kalpha, IC50s = 4.6, 4, and 4.8 nM for wild-type, E545K mutant, and H1047R mutant PI3K, respectively). It is selective for PI3Kalpha over PI3Kbeta, PI3Kdelta, PI3Kgamma, and PI4Kbeta (IC50s = 1,156, 290, 250, and 581 nM, respectively), as well as VPS34,...
Keywords: Alpelisib, NVP-BYL719,...
Application: PI3Kalpha inhibitor
CAS 1217486-61-7
MW: 441.5 D
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Quizartinib
Quizartinib

Item number: Cay17986-5

Quizartinib is an inhibitor of FMS-related tyrosine kinase 3 (FLT3, Kd = 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases. It inhibits the proliferation of the human leukemia cell line MV4-11, which harbors a homozygous FLT3-ITD mutation, with an IC50 value of...
Keywords: AC220, N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-N'-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]-urea
Application: FLT3 inhibitor
CAS 950769-58-1
MW: 560.7 D
From 39.00€ *
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