Alendronate (sodium hydrate)

Alendronate (sodium hydrate)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13642-100 100 mg -

6 - 10 business days*

38.00€
Cay13642-250 250 mg -

6 - 10 business days*

81.00€
Cay13642-500 500 mg -

6 - 10 business days*

130.00€
Cay13642-1 1 g -

6 - 10 business days*

158.00€
 
Alendronate is an amino bisphosphonate that inhibits farnesyl pyrophosphate (FPP) synthase (IC50... more
Product information "Alendronate (sodium hydrate)"
Alendronate is an amino bisphosphonate that inhibits farnesyl pyrophosphate (FPP) synthase (IC50 = 50 nM for the recombinant human enzyme). It inhibits bone resorption in a pit formation assay using isolated rat osteoclasts (IC50 = 2 nM). Alendronate (3 and 10 µM) reduces angiotensin II-induced collagen I synthesis in isolated rat cardiac fibroblasts. It prevents femoral bone mineral density loss in ovariectomized rats when administered at a dose of 5 mg/kg. Formulations containing alendronate have been used in the treatment of osteoporosis and Paget's disease.Formal Name: P,P'-(4-amino-1-hydroxybutylidene)bis-phosphonic acid, monosodium salt trihydrate (1:1:3). CAS Number: 121268-17-5. Synonyms: Adronat, Fosamax, G-704650, MK-217. Molecular Formula: C4H12NO7P2 . H6NaO3. Formula Weight: 325.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 0.25 mg/ml. SMILES: NCCCC(P(O)([O-])=O)(O)P(O)(O)=O.[Na+]. InChi Code: InChI=1S/C4H13NO7P2.Na/c5-3-1-2-4(6,13(7,8)9)14(10,11)12,/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12),/q,+1/p-1. InChi Key: CAKRAHQRJGUPIG-UHFFFAOYSA-M.
Keywords: Adronat, Fosamax, G-704650, MK-217, P,P'-(4-amino-1-hydroxybutylidene)bis-phosphonic acid, monosodium salt trihydrate (1:1:3)
Supplier: Cayman Chemical
Supplier-Nr: 13642

Properties

Application: Bone resorption inhibitor
MW: 325.1 D
Formula: C4H12NO7P2 . H6NaO3
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 121268-17-5| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H302, H315, H318, H335, H361, H373
P Phrases: P201, P202, P260, P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P308+313, P310, P312, P314, P321, P330, P332+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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