- Search results for Cay11425
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15 products were found matching "Cay11425"!
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Item number: Cay11425-1
Alamethicin is an antibiotic peptide belonging to a class of membrane active peptides of fungal origin called peptaibols. It contains an unusual amphiphilic amino acid, 2-aminoisobutyric acid, which strongly induces helical peptide structures and forms voltage-gated ion channels in the lipid bilayers of cell...
Keywords: | Antibiotic U-22324,... |
Application: | Ion channel assembly studies |
CAS | 27061-78-5 |
MW: | 1964.3 D |
From 60.00€
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Item number: Cay11442-5
Tentoxin is a cyclic tetrapeptide first isolated from the plant pathogen A. alternata. It is an herbicide that inhibits chloroplast development, resulting in chlorotic tissue. Tentoxin is selectively phytotoxic, as it kills a number of important weeds at concentrations that have no effects on several important...
Keywords: | cyclo[N-methyl-L-alanyl-L-leucyl-(alphaZ)-alpha,beta-didehydro-N-methylphenylalanylglycyl] |
Application: | Herbicide, chloroplast development inhibitor |
CAS | 28540-82-1 |
MW: | 414.5 D |
From 259.00€
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Item number: Cay14422-5
Doxycycline is a broad-spectrum tetracycline antibiotic. It inhibits bacterial protein synthesis by binding to ribosomes. Doxycycline also selectively inhibits human matrix metalloproteinase-8 (MMP-8) and MMP-13 over MMP-1 with 50, 60, and 5% inhibition, respectively, when used at a concentration of 30 µM. It can be...
Keywords: | (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-... |
Application: | Antibiotic |
CAS | 24390-14-5 |
MW: | 1025.9 D |
From 43.00€
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Item number: Cay11422-5
R406 is a potent ATP-competitive inhibitor of spleen tyrosine kinase (Syk, Ki = 30 nM). Through this action, R406 blocks FcepsilonRI-dependent mast cell activation (EC50 = 43 nM) and, at 3 µM, reduces the release of IL-10, -12, and -13 by immune complex-pulsed dendritic cells. R406 is orally available and can reduce...
Keywords: | 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one |
Application: | Potent ATP-competitive Syk inhibitor |
CAS | 841290-80-0 |
MW: | 470.5 D |
From 92.00€
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Item number: Cay14425-25
Teniposide is a topoisomerase II poison. It promotes calf thymus topoisomerase II-mediated DNA cleavage when used at concentrations ranging from 0.04 to 40 µg/ml. Teniposide induces single- and double-stranded DNA breaks in a concentration-dependent manner. It inhibits the proliferation of A549 lung cancer cells...
Keywords: | NSC 122819, VM-26,... |
Application: | Topoisomerase II inhibitor |
CAS | 29767-20-2 |
MW: | 656.7 D |
From 43.00€
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Item number: Cay11421-5
Actinomycin D is a cyclic polypeptide-containing antibiotic that binds to DNA and blocks transcription. It binds to pre-melted double-stranded DNA in transcription bubbles and once bound is slow to dissociate. DNA in transcriptionally hyperactive cancer cells efficiently and rapidly bind actinomycin D at low...
Keywords: | Cosmegen, Dactinomycin, Meractinomycin, NCI C04682, NSC 3053, Oncostatin K,... |
Application: | Cancer studies, antineoplastic |
CAS | 50-76-0 |
MW: | 1255.5 D |
From 90.00€
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Item number: Cay11426-5
Beauvericin is a mycotoxin originally derived from B. bassiana, a common fungal parasite of arthropods. It is also produced by the fungus Fusarium, a pathogen of insects and plants. Beauvericin is cytotoxic against insect cells, killing the insect cell line SF-9 with a 50% cytotoxic concentration of 2.5 µM. In...
Keywords: | cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl-(2R)... |
Application: | Mycotoxin, Apotosis inducer |
CAS | 26048-05-5 |
MW: | 784 D |
From 43.00€
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Item number: Cay11428-5
4-deoxy Nivalenol is a trichothecene mycotoxin that has been found in Fusarium. It binds to eukaryotic ribosomes and inhibits protein synthesis in mice when administered at doses ranging from 5 to 25 mg/kg. 4-deoxy Nivalenol (0.1 and 0.2 mg/kg) induces emesis in pigs and decreases feed consumption in pigs when...
Keywords: | Deoxynivalenol, DON, NSC 269144, Vomitoxin, 12,13-epoxy-3alpha,7alpha,15-trihydroxy-trichothec-9-en-8-one |
Application: | Type B trichothecene mycotoxin, Protein biosynthesis inhibitor |
CAS | 51481-10-8 |
MW: | 296.3 D |
From 66.00€
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Item number: Cay11427-5
diacetoxy Scirpenol is a trichothecene mycotoxin originally isolated from F. equiseti. It is toxic to pigs (LD50 = 0.38 mg/kg, i.v.) and lethal to brine shrimp (LC50 = 0.39 µg/ml). diacetoxy Scirpenol (1 µg/ml) suppresses phagocytosis by, and superoxide production in, isolated mouse macrophages in an S. cerevisiae...
Keywords: | Anguidin, DAS, NSC 141537, NSC 177378, Scirpenetriol 4,15-diacetate,... |
Application: | Plant pathogen studies |
CAS | 2270-40-8 |
MW: | 366.4 D |
From 107.00€
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Item number: Cay11429-5
3-Acetyldeoxy nivalenol is a mycotoxin that has been found in F. graminearum. In vivo, 3-acetyldeoxy nivalenol (40 mg/kg) induces duodenal and splenic cell necrosis, as well as lethality (LD50 = 70 mg/kg) in mice.Formal Name: (3alpha,7alpha)-3-(acetyloxy)-12,13-epoxy-7,15-dihydroxy-trichothec-9-en-8-one. CAS Number:...
Keywords: | 3-AcDON, deoxy Nivalenol 3-acetate, DON 3-acetate, NSC 267036,... |
Application: | Mycotoxin |
CAS | 50722-38-8 |
MW: | 338.4 D |
From 142.00€
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Item number: Cay11423-5
BAY 61-3606 is an inhibitor of spleen tyrosine kinase (Syk, Ki = 7.5 nM). It is selective for Syk over Lyn, Fyn, Src, Itk, and BTK (Kis = >4.7 µM for all). BAY 61-3606 inhibits anti-IgE-induced histamine release in isolated human mast cells sensitized with IgE (IC50 = 5.1 nM), as well as reduces anti-IgM-induced...
Keywords: | 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide, monohydrochloride |
Application: | Cell-permeable, reversible Syk inhibitor |
CAS | 1615197-10-8 |
MW: | 426.9 D |
From 77.00€
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Item number: Cay11437-25
Nigericin is a lipophilic potassium ionophore that has been found in S. hygroscopicus. It mediates neutral antiport of potassium and proton ions across mitochondrial membranes. Nigericin (10 µM) induces T. gondii egress in infected human foreskin fibroblasts (HFFs). It also induces NOD-like receptor protein 3...
Keywords: | NSC 292567,... |
Application: | Metabolic studies |
CAS | 28643-80-3 |
MW: | 747 D |
From 77.00€
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