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Akt1, active, Recombinant, Human (Rac PKa, PKBa)

ART NR.: A1125-01L.10 (10 µg)

Hersteller: USBio

Datenblatt

Anwendungen: Enzyme assays

Format: highly purified

Lagerung: -20°C

Versand: +4°C

UniProt ID: P31749
Suche mit UniProt ID

Geninformationen: GeneID 207

Schlagworte: PKB alpha, EC=2.7.11.1, RAC-PK-alpha, Protein kinase B, Proto-oncogene c-Akt, Protein kinase B alpha, RAC-alpha serine/threonine-protein kinase

A1125-01L.10

10 µg

480 €

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Bemerkungen: AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis

Spezifikationen

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