- Search results for Cay16160
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25 products were found matching "Cay16160"!
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Item number: Cay16160-10
Acetyl-coenzyme A (acetyl-CoA), the thioester of CoA (Cay-16147) and acetic acid, is a pivotal molecule in biological systems. Foremost, it serves as a source of carbon for the Krebs cycle, for the synthesis of fatty acids, and for isoprenoid-based protein modifications. Acetyl-CoA also serves as an intermediate in...
Keywords: | Acetyl-CoA, S-acetate coenzyme A, trisodium salt |
Application: | Krebs cycle intermediate |
CAS | 102029-73-2 |
MW: | 878.5 D |
From 44.00€
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Item number: Cay16169-10
2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) is a cyclic oligosaccharide containing seven D-(+)-glucopyranose units that is widely used to improve the aqueous solubility of various compounds, especially those containing a phenyl group. The circular arrangement of its glucose units produces a torus-shaped ring...
Keywords: | HP-beta-CD, 2-hydroxypropyl ethers beta-cyclodextrin |
Application: | Solubility enhancer |
CAS | 128446-35-5 |
MW: | 1541.6 D |
From 44.00€
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Item number: Cay16165-10
ISX-9 is a small molecule inducer of adult neural stem cell differentiation both in vitro and in vivo. At 2.5-20 µM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer...
Keywords: | Isoxazole 9, Neuronal Differentiation Inducer III, N-cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide |
Application: | Adult neural stem cell differentiation inducer |
CAS | 832115-62-5 |
MW: | 234.3 D |
From 43.00€
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Item number: Cay16164-10
Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. GSA 10 is a quinolinecarboxamide derivative that acts as an agonist of SMO. By acting at SMO, GSA 10 has been shown to promote the differentiation of...
Keywords: | 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-benzoic acid, propyl ester |
Application: | SMO agonist |
CAS | 300833-95-8 |
MW: | 450.5 D |
From 114.00€
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Item number: Cay16162-10
gamma-Secretase is a multi-subunit aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. One well-known substrate of this enzyme is Notch, a transmembrane receptor that plays a key role in cell fate decisions including cell...
Keywords: | N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alphaS-hydr... |
Application: | gamma-?secretase inhibitor |
CAS | 209984-57-6 |
MW: | 479.5 D |
From 50.00€
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Item number: Cay16168-10
The VEGF receptors (VEGFRs) mediate signaling leading to angiogenesis, with VEGFR3 (FLT4), activated by VEGF isoforms VEGFC and VEGFD, primarily expressed on lymphatic endothelial cells and directing lymphangiogenesis. MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1...
Keywords: | 3-[[4-(dimethylamino)-1-naphthalenyl]methylene]-1,3-dihydro-2H-indol-2-one |
Application: | VEGFR-3 VEGF-C antagonist |
CAS | 163655-37-6 |
MW: | 314.4 D |
From 66.00€
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Item number: Cay16161-50
PluriSln 1 is an N-acyl phenylhydrazine derivative that inhibits stearoyl-CoA desaturase, a key enzyme for lipid metabolism that is expressed in human pluripotent stem cells (hPSCs). PluriSln 1 can selectively induce ER stress, attenuate protein synthesis, and induce apoptosis in hPSCs (EC50 = 2 µM) while sparing...
Keywords: | N'-phenyl-hydrazine-Isonicotinic acid, NSC 14613, 2-phenylhydrazide-4-pyridinecarboxylic acid |
Application: | Stearoyl-CoA desaturase inhibitor, HPSC apoptosis inducer |
CAS | 91396-88-2 |
MW: | 213.2 D |
From 84.00€
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Item number: Cay16361-10
3,4-Methylenedioxy Pyrovalerone (3,4-MDPV, Cay-10684) is a central nervous system stimulant that has been widely abused. 3,4-Methylenedioxy-alpha-pyrrolidinohexanophenone (3,4-MDPHP) is an analog of 3,4-MDPV that differs only by the addition of a single carbon to the alkyl chain. The physiological and toxicological...
Keywords: | 3,4-MDPHP, 3,4-MD-alpha-PHP, 1-(1,3-benzodioxol-5-yl)-2-(1-pyrrolidinyl)-1hexanone, monohydrochloride |
Application: | Analytical reference standard, 3,4-MDPV analog |
CAS | 24622-61-5 |
MW: | 325.8 D |
From 280.00€
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Item number: Cay16761-10
AS-1842856 is a potent inhibitor of forkhead box class O transcription factor 1 (FoxO1, IC50 = 33 nM in HepG2 cells). Inhibition of FoxO1-mediated transactivation with AS-1842856 leads to a dose-dependent decrease in expression of glucose-6 phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) mRNA and...
Keywords: | FOXO1 Inhibitor, 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid |
Application: | Foxo1 Inhibitor |
CAS | 836620-48-5 |
MW: | 347.4 D |
From 42.00€
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Item number: Cay16261-10
The Ras family of small GTPases (H-Ras, K-Ras, and N-Ras) function as molecular switches, cycling between a GTP-bound active state and a GDP-bound inactive state, to turn on downstream Raf protein kinases. This initiates complex signaling pathways involved in cell growth, differentiation, and apoptosis. Mutations...
Keywords: | N-(3-chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-hydrazinecarbothioamide |
Application: | Ras inhibitor |
CAS | 436133-68-5 |
MW: | 449.8 D |
From 50.00€
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Item number: Cay16961-10
Arylquin 1 is a prostate apoptosis response-4 (Par-4) secretagogue. It binds to vimentin to displace Par-4 for secretion. Arylquin 1 induces Par-4 secretion from mouse embryonic fibroblasts (MEFs) and prostate cancer cells in vitro, effects that can be blocked by the inhibitor of vesicular transport brefeldin A...
Keywords: | 3-(2-fluorophenyl)-N7,N7-dimethyl-2,7-quinolinediamine |
Application: | PAWR secretagogue |
CAS | 1630743-73-5 |
MW: | 281.3 D |
From 43.00€
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Item number: Cay16861-10
Cycloguanil is the active metabolite of the antimalarial prodrug proguanil. Cycloguanil is formed from proguanil by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A in human liver microsomes. It is an inhibitor of dihydrofolate reductase (DHFR, Kis = 1.5 and 0.79 nM for the P. falciparum and P. berghei enzymes,...
Keywords: | Chloroguanide Triazine, NSC 3074, 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine, monohydrochloride |
Application: | DHFR inhibitor |
CAS | 152-53-4 |
MW: | 288.2 D |
From 43.00€
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