25 products were found matching "Cay16160"!

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Acetyl-Coenzyme A (sodium salt)
Acetyl-Coenzyme A (sodium salt)

Item number: Cay16160-10

Acetyl-coenzyme A (acetyl-CoA), the thioester of CoA (Cay-16147) and acetic acid, is a pivotal molecule in biological systems. Foremost, it serves as a source of carbon for the Krebs cycle, for the synthesis of fatty acids, and for isoprenoid-based protein modifications. Acetyl-CoA also serves as an intermediate in...
Keywords: Acetyl-CoA, S-acetate coenzyme A, trisodium salt
Application: Krebs cycle intermediate
CAS 102029-73-2
MW: 878.5 D
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2-Hydroxypropyl-beta-cyclodextrin
2-Hydroxypropyl-beta-cyclodextrin

Item number: Cay16169-10

2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) is a cyclic oligosaccharide containing seven D-(+)-glucopyranose units that is widely used to improve the aqueous solubility of various compounds, especially those containing a phenyl group. The circular arrangement of its glucose units produces a torus-shaped ring...
Keywords: HP-beta-CD, 2-hydroxypropyl ethers beta-cyclodextrin
Application: Solubility enhancer
CAS 128446-35-5
MW: 1541.6 D
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ISX-9
ISX-9

Item number: Cay16165-10

ISX-9 is a small molecule inducer of adult neural stem cell differentiation both in vitro and in vivo. At 2.5-20 µM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer...
Keywords: Isoxazole 9, Neuronal Differentiation Inducer III, N-cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide
Application: Adult neural stem cell differentiation inducer
CAS 832115-62-5
MW: 234.3 D
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GSA 10
GSA 10

Item number: Cay16164-10

Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. GSA 10 is a quinolinecarboxamide derivative that acts as an agonist of SMO. By acting at SMO, GSA 10 has been shown to promote the differentiation of...
Keywords: 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-benzoic acid, propyl ester
Application: SMO agonist
CAS 300833-95-8
MW: 450.5 D
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LY411575
LY411575

Item number: Cay16162-10

gamma-Secretase is a multi-subunit aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. One well-known substrate of this enzyme is Notch, a transmembrane receptor that plays a key role in cell fate decisions including cell...
Keywords: N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alphaS-hydr...
Application: gamma-?secretase inhibitor
CAS 209984-57-6
MW: 479.5 D
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MAZ51
MAZ51

Item number: Cay16168-10

The VEGF receptors (VEGFRs) mediate signaling leading to angiogenesis, with VEGFR3 (FLT4), activated by VEGF isoforms VEGFC and VEGFD, primarily expressed on lymphatic endothelial cells and directing lymphangiogenesis. MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1...
Keywords: 3-[[4-(dimethylamino)-1-naphthalenyl]methylene]-1,3-dihydro-2H-indol-2-one
Application: VEGFR-3 VEGF-C antagonist
CAS 163655-37-6
MW: 314.4 D
From 66.00€ *
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PluriSln 1
PluriSln 1

Item number: Cay16161-50

PluriSln 1 is an N-acyl phenylhydrazine derivative that inhibits stearoyl-CoA desaturase, a key enzyme for lipid metabolism that is expressed in human pluripotent stem cells (hPSCs). PluriSln 1 can selectively induce ER stress, attenuate protein synthesis, and induce apoptosis in hPSCs (EC50 = 2 µM) while sparing...
Keywords: N'-phenyl-hydrazine-Isonicotinic acid, NSC 14613, 2-phenylhydrazide-4-pyridinecarboxylic acid
Application: Stearoyl-CoA desaturase inhibitor, HPSC apoptosis inducer
CAS 91396-88-2
MW: 213.2 D
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3,4-Methylenedioxy-alpha-Pyrrolidinohexanophenone (hydrochloride)
3,4-Methylenedioxy-alpha-Pyrrolidinohexanophenone...

Item number: Cay16361-10

3,4-Methylenedioxy Pyrovalerone (3,4-MDPV, Cay-10684) is a central nervous system stimulant that has been widely abused. 3,4-Methylenedioxy-alpha-pyrrolidinohexanophenone (3,4-MDPHP) is an analog of 3,4-MDPV that differs only by the addition of a single carbon to the alkyl chain. The physiological and toxicological...
Keywords: 3,4-MDPHP, 3,4-MD-alpha-PHP, 1-(1,3-benzodioxol-5-yl)-2-(1-pyrrolidinyl)-1hexanone, monohydrochloride
Application: Analytical reference standard, 3,4-MDPV analog
CAS 24622-61-5
MW: 325.8 D
From 280.00€ *
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AS-1842856
AS-1842856

Item number: Cay16761-10

AS-1842856 is a potent inhibitor of forkhead box class O transcription factor 1 (FoxO1, IC50 = 33 nM in HepG2 cells). Inhibition of FoxO1-mediated transactivation with AS-1842856 leads to a dose-dependent decrease in expression of glucose-6 phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) mRNA and...
Keywords: FOXO1 Inhibitor, 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Application: Foxo1 Inhibitor
CAS 836620-48-5
MW: 347.4 D
From 42.00€ *
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Kobe 0065
Kobe 0065

Item number: Cay16261-10

The Ras family of small GTPases (H-Ras, K-Ras, and N-Ras) function as molecular switches, cycling between a GTP-bound active state and a GDP-bound inactive state, to turn on downstream Raf protein kinases. This initiates complex signaling pathways involved in cell growth, differentiation, and apoptosis. Mutations...
Keywords: N-(3-chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-hydrazinecarbothioamide
Application: Ras inhibitor
CAS 436133-68-5
MW: 449.8 D
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Arylquin 1
Arylquin 1

Item number: Cay16961-10

Arylquin 1 is a prostate apoptosis response-4 (Par-4) secretagogue. It binds to vimentin to displace Par-4 for secretion. Arylquin 1 induces Par-4 secretion from mouse embryonic fibroblasts (MEFs) and prostate cancer cells in vitro, effects that can be blocked by the inhibitor of vesicular transport brefeldin A...
Keywords: 3-(2-fluorophenyl)-N7,N7-dimethyl-2,7-quinolinediamine
Application: PAWR secretagogue
CAS 1630743-73-5
MW: 281.3 D
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Cycloguanil (hydrochloride)
Cycloguanil (hydrochloride)

Item number: Cay16861-10

Cycloguanil is the active metabolite of the antimalarial prodrug proguanil. Cycloguanil is formed from proguanil by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A in human liver microsomes. It is an inhibitor of dihydrofolate reductase (DHFR, Kis = 1.5 and 0.79 nM for the P. falciparum and P. berghei enzymes,...
Keywords: Chloroguanide Triazine, NSC 3074, 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine, monohydrochloride
Application: DHFR inhibitor
CAS 152-53-4
MW: 288.2 D
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