Ac-DEVD-CMK (trifluoroacetate salt)

Ac-DEVD-CMK is a cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, -7, -8, and -10. It is commonly used at concentrations up to 100 µM to examine the role of caspase-3-dependent apoptosis in biological systems.Formal Name: N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-L-valinamide, 2,2,2-trifluoroacetate salt. Synonyms: Ac-Asp-Glu-Val-Asp-CMK, Caspase-3 Inhibitor III. Molecular Formula: C21H31ClN4O11 . XCF3COOH. Formula Weight: 551.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 50 mg/ml. SMILES: CC(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(CCl)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C21H31ClN4O11.C2HF3O2/c1-9(2)18(21(37)25-12(6-16(31)32)14(28)8-22)26-19(35)11(4-5-15(29)30)24-20(36)13(7-17(33)34)23-10(3)27,3-2(4,5)1(6)7/h9,11-13,18H,4-8H2,1-3H3,(H,23,27)(H,24,36)(H,25,37)(H,26,35)(H,29,30)(H,31,32)(H,33,34),(H,6,7)/t11-,12-,13-,18-,/m0./s1. InChi Key: CLHNKMMUCVHOBN-URZJWRBXSA-N.