11 products were found matching "Cay16731"!

Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F)....

1-Azakenpaullone is an analog of kenpaullone (Cay-10010239) that inhibits glycogen synthase kinase 3beta (GSK3beta) more potently (IC50 = 18 nM) than CDK1/cyclin B or CDK5/p25 (IC50s = 2.0 and 4.2 µM, respectively). Through its effects on GSK3beta, 1-azakenpaullone stimulates the proliferation of human pancreatic...

(-)-Norepinephrine is the endogenous isomer of (±)-norepinephrine (Cay-35580) that acts as a neurotransmitter and hormone and is biosynthesized from dopamine by dopamine beta-hydroxylase. It is an agonist of adrenergic receptors (Ki values are 330, 56, and 740 nM for alpha1, alpha2, and beta1 adrenoceptors,...

alpha-acetyl Boswellic acid is a pentacyclic triterpene and isomer of beta-acetyl-boswellic acid (Cay-11674) originally isolated from B. serrata. It inhibits LPS-induced TNF-alpha mRNA expression in monocytes as well as NF-kappaB activity in HEK293 cells when used at a concentration of 10 µM. alpha-acetyl Boswellic...

AL 8810 is an 11beta-fluoro analog of PGF2alpha which acts as a potent and selective antagonist at the FP receptor. AL 8810 has weak intrinsic agonist activity on FP receptor preparations in the 200-300 nM range, yet it fully antagonizes the activity of the potent FP receptor agonist fluprostenol at this...

Goat anti-Mouse IgG, H+L conjugated to HRP Antibody: Goat polyclonal anti-Mouse IgG, H+L Enzyme: Horseradish Peroxidase Uses: ELISA and Western blot detection. Recommended dilution of 1:500-1:10,000. Starting dilution: 1:2,000.Formulation: (Request formulation change), A lyophilized powder. Applications: ELISA, WB....

15(R)-15-methyl Prostaglandin F2alpha methyl ester (15(R)-15-methyl PGF2alpha methyl ester) is a lipid soluble prodrug form of 15(R)-15-methyl PGF2alpha (Cay-16730) with increased membrane permeability. Acid-catalyzed epimerization of 15(R)-15-methyl PGF2alpha methyl ester and hydrolysis of the ester converts it...

15(R)-15-methyl PGF2alpha is a metabolically stable analog of PGF2alpha. 15(R)-15-methyl PGF2alpha is an inactive, prodrug PGF agonist designed for activation by gastric acid after oral administration. Acid-catalyzed epimerization of 15(R)-15-methyl PGF2alpha converts it into the active 15(S)-isomer. The...

Janus kinases (JAKs) are non-receptor kinases that mediate signaling through cytokine receptors, often to members of the signal transducer and activator of transcription family. CEP-33779 is a potent, orally available inhibitor of JAK2 (IC50 = 1.3 nM). It shows 65-fold selectivity for JAK2 over JAK3. In mouse models...

Goat anti-Human IgG, Fc-specific conjugated to HRP Antibody: Goat polyclonal anti-Human IgG Isotype: IgG Enzyme: Horseradish Peroxidase Uses: ELISA and Western blot detection. Recommended dilution of 1:500-1:10,000. Starting dilution: 1:2,000.Formulation: (Request formulation change), A lyophilized powder. Isotype:...

Goat anti-Mouse IgG, Fc-specific conjugated to HRPAntibody: Goat polyclonal anti-Mouse IgG, Fc-specific Enzyme: Horseradish Peroxidase Uses: ELISA and Western blot detection. Recommended dilution of 1:500 - 1:10000. Starting dilution: 1:2000Formulation: (Request formulation change), A lyophilized powder....