11 products were found matching "Cay16875"!

AZ 505 is an inhibitor of the lysine N-methyltransferase SMYD2 (IC50 = 0.12 µM). It is selective for SMYD2 over SMYD3, DOT1L, EZH2, GLP, G9A, and SET7/9 (IC50s = >83.3 µM). AZ 505 (10 mg/kg) delays cyst growth in early- and late-stage Pdk1 conditional knockout mouse models of polycystic kidney disease.Formal Name:...

1'-Napthoyl indole (Cay-11687) is an analytical reference standard categorized as a precursor in the synthesis of synthetic cannabinoids. This product is intended for research and forensic applications.Formal Name: 1H-indol-3-yl-1-naphthalenyl-methanone. CAS Number: 109555-87-5. Molecular Formula: C19H13NO. Formula...

The glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are responsible for a majority of nutrient-stimulated insulin secretion. After being released into the circulation, GIP and GLP-1 are inactivated by the circulating enzyme dipeptidyl peptidase IV (DPP IV). DPP IV inhibitors...

Phosphatidylethanolamine is the most abundant phospholipid in prokaryotes and the second most abundant found in the membrane of mammalian, plant, and yeast cells, comprising approximately 25% of total mammalian phospholipids. In the brain, phosphatidylethanolamine comprises almost half of the total phospholipids. It...

Maternal embryonic leucine zipper kinase (MELK) is a serine/threonine kinase that regulates signaling central to cell cycling, stem cell renewal, apoptosis, and other cellular processes. MELK is overexpressed in some forms of cancer, particularly those with aggressive undifferentiated tumors. OTSSP167 is a potent...

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. AZD 2461 is a PARP inhibitor (IC50 = 5 nM) with low affinity for the P-glycoprotein drug efflux transporter. It was developed to overcome the...

I-BET726 is an inhibitor of BET family proteins that binds BRD2, BRD3, and BRD4 with high affinity (IC50s = 41, 31, and 22 nM, respectively) and competes with tetra-acetylated histone 4 peptides for binding to the bromodomains of these proteins. It exhibits >1,000-fold selectivity for these proteins over other...

Nexturastat A is a potent inhibitor of HDAC6 (IC50 = 5.02 nM) that displays high selectivity over all other HDACs. It dose-dependently induces hyperacetylation of alpha-tubulin in B16 murine melanoma cells without elevating histone H3 acetylation. Nexturastat A is cell-permeable and inhibits the proliferation of B16...

R-7050 is a cell-permeable antagonist of signaling through the TNF-alpha receptor complex (EC50 = 0.631 µM). It blocks TNF-alpha-induced binding of TNF-alpha receptor I with TNF-alpha receptor-associated death domain protein and receptor interacting protein 1, which, in turn, prevents internalization of the receptor...

Emtricitabine is a nucleoside analog and an inhibitor of HIV-1 and hepatitis B reverse transcriptase with antiviral activity. It inhibits replication of HIV-1 (EC50s = 10-20 nM) and hepatitis B (EC50s = 10-40 nM) in various cell lines. Emtricitabine inhibits duck hepatitis B viral DNA synthesis when administered...

Lipopolysaccharides (LPS) are components of the cell walls of Gram-negative bacteria. LPS is composed of polysaccharides and lipid A, where lipid A is a phosphoglycolipid containing acyl chains composed of 10 to 16 carbons. The lipid A component of LPS is detected by Toll-like receptor 4 of mammalian leukocytes and,...