AX 048

AX 048
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13823-500 500 µg -

6 - 10 business days*

189.00€
Cay13823-1 1 mg -

6 - 10 business days*

358.00€
Cay13823-5 5 mg -

6 - 10 business days*

1,224.00€
 
The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2),... more
Product information "AX 048"
The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes. AX 048 is a potent group IVA cPLA2 inhibitor that demonstrates 50% inhibition of the enzyme at a mole fraction (XI(50)) of 0.022. Pretreatment with AX 048 (ED50 = 1.2 mg/kg) dose-dependently reduces thermal hyperalgesia evoked by carrageenan injection of rat hind paw. At concentrations as high as 30 µM, AX 048 does not inhibit COX activity or interfere with central cannabinoid receptor signaling.Formal Name: 4-[(1,2-dioxohexadecyl)amino]-butanoic acid, ethyl ester. CAS Number: 873079-69-7. Molecular Formula: C22H41NO4. Formula Weight: 383.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 2 mg/ml, Ethanol: 5 mg/ml. lambdamax: 242 nm. SMILES: O=C(C(NCCCC(OCC)=O)=O)CCCCCCCCCCCCCC. InChi Code: InChI=1S/C22H41NO4/c1-3-5-6-7-8-9-10-11-12-13-14-15-17-20(24)22(26)23-19-16-18-21(25)27-4-2/h3-19H2,1-2H3,(H,23,26). InChi Key: FMFKQXKYWWJNJS-UHFFFAOYSA-N.
Keywords: 4-[(1,2-dioxohexadecyl)amino]-butanoic acid, ethyl ester
Supplier: Cayman Chemical
Supplier-Nr: 13823

Properties

Application: cPLA2 inhibitor
MW: 383.6 D
Formula: C22H41NO4
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 873079-69-7| Matching products
KEGG ID : K16342 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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