8 products were found matching "Cay16235"!

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AWD 131-138
AWD 131-138

Item number: Cay16235-25

AWD 131-138 is a partial agonist of the GABAA receptor that acts at the benzodiazepine binding site, dose-dependently stimulating GABA currents with a threshold of 0.3-1.0 µM. This effect is blocked by the benzodiazepine antagonist flumazenil (Cay-14252). AWD 131-138 displays a broad spectrum of anticonvulsant...
Keywords: ELB138, Imepitoin, 1-(4-chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)-2H-imidazol-2-one
Application: Partial benzodiazepine receptor agonist
CAS 188116-07-6
MW: 279.7 D
From 142.00€ *
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Kanosamine (hydrochloride)
Kanosamine (hydrochloride)

Item number: Cay16623-5

Kanosamine, a constituent of kanamycin, is an antibiotic produced by Streptomyces and Bacillus that can inhibit cell wall synthesis in plant-pathogenic oomycetes (MIC = 25 µg/ml for P. medicaginis M2913) and certain fungi as well as some bacterial species (MIC = 400 µg/ml for S. aureus). It has been explored as an...
Keywords: 3-amino-3-deoxy-D-glucose, monohydrochloride
Application: Antibiotic
CAS 57649-10-2
MW: 215.6 D
From 60.00€ *
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BMS 303141
BMS 303141

Item number: Cay16239-5

ATP citrate lyase (ACL) catalyzes the synthesis of acetyl-CoA and oxaloacetate using citrate, CoA, and ATP as substrates and Mg2+ as a cofactor. The ACL-dependent synthesis of acetyl-CoA is important for the de novo synthesis of fatty acids and cholesterol. Furthermore, as a key enzyme for linking glucose and lipid...
Keywords: 3,5-dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide
Application: ATP citrate lyase (ACL) inhibitor
CAS 943962-47-8
MW: 424.3 D
From 125.00€ *
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AZD 9291
AZD 9291

Item number: Cay16237-5

AZD 9291 is an inhibitor of mutant EGFRs (IC50s = 1, 12, and 5 nM for EGFRL858R/T790M, EGFRL858R, and EGFRL861Q, respectively). It is selective for these mutant EGFRs over wild-type EGFR (IC50 = 184 nM), as well as over a panel of approximately 280 other kinases at 1 µM. AZD 9291 selectively inhibits the...
Keywords: Osimertinib,...
Application: Mutant-selective EGFR inhibitor
CAS 1421373-65-0
MW: 499.6 D
From 43.00€ *
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AT7519 (hydrochloride)
AT7519 (hydrochloride)

Item number: Cay16231-5

AT7519 is an ATP-competitive inhibitor of cyclin-dependent kinases (Cdks) with IC50 values of 210, 47, 100, 13, 170, and 50 = 89 nM). AT7519 demonstrates antiproliferative activity against a wide variety of human tumor cell lines (IC50s = 40-940 nM in vitro), inhibiting cell cycle progression and inducing apoptosis,...
Keywords: 4-[(2,6-dichlorobenzoyl)amino]-N-4-piperidinyl-1H-pyrazole-3-carboxamide, monohydrochloride
Application: CDK inhibitor
CAS 902135-91-5
MW: 418.7 D
From 43.00€ *
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BIX02188
BIX02188

Item number: Cay16238-5

BIX02188 is a potent inhibitor of MEK5 (IC50 = 4.3 nM) with reduced activity towards inhibition of ERK5 and TGFbetaR1 (IC50s = 810 and 1,800 nM, respectively). It does not inhibit the closely related kinases MEK1, MEK2, ERK2, and JNK2 (IC50s = > 6,300 nM). BIX02188 inhibits phosphorylation of ERK5 in a...
Keywords: (3Z)-3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide
Application: MEK5 inhibitor
CAS 334949-59-6
MW: 412.5 D
From 60.00€ *
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ATB-346
ATB-346

Item number: Cay16234-5

ATB-346 is a non-steroidal anti-inflammatory drug (NSAID) that releases hydrogen sulfide (H2S) and a derivative of naproxen (Cay-70290). It inhibits the proliferation of, and induces apoptosis in, A375 melanoma cells when used at a concentration of 100 µM. ATB-346 decreases prostaglandin E2 (PGE2) production in...
Keywords: 6-methoxy-alpha-methyl-2-naphthaleneacetic acid, 4-(aminothioxomethyl)phenyl ester
Application: Antiinflammatory agent
CAS 1226895-20-0
MW: 365.5 D
From 98.00€ *
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ABT-199
ABT-199

Item number: Cay16233-25

B-cell lymphoma/leukemia 2 (Bcl-2) is an anti-apoptotic protein that controls cell survival by binding the BH3 domains of pro-death BAD and BAK proteins and preventing permeabilization of the mitochondrial outer membrane. This protein is tightly regulated for the homeostasis between cell growth and cell death. The...
Keywords: Venetoclax, GDC 0199,...
Application: BCL-2 inhibitor
CAS 1257044-40-8
MW: 868.4 D
From 72.00€ *
Review