48 products were found matching "502"!

BMS 502 is an inhibitor of diacylglycerol kinase alpha (DGK-alpha), DGK-zeta, and DGK-iota (IC50s = 0.0046, 0.0021, and 0.0026 µM, respectively). It is selective for these DGKs over DGK-beta, DGK-gamma, and DGK-kappa (IC50s = 1, 0.68, and 4.6 µM, respectively). BMS 502 increases levels of IFN-gamma and...

AMCA is one of the brightest blue fluorescent labeling dyes. It can be well excited at 365 nm. It is quite photostable, and its fluorescence is pH-independent from pH 4 to 10.

TRAM, or TRIF-related adaptor molecule, plays an essential role in the MyD88-independent signaling of TLR4. The functional absence of TRAM in vascular endothelial cells restricts TLR4 signaling to MyD88-dependent pathway. Overexpression of TRAM cDNA in endothelial cells reconstituted LPS-induced Trif-dependent NF-êB...

Anti-TLR4 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. TLR4 antibody is predicted to not cross-react with other TLR protein family members. Protein function: Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate...

Anti-TLR5 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with TLR5 from other sources has not been determined. Protein function: Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune...

TIRP is a Toll/interleukin-1 receptor (IL1R, MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling Protein function: Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and...

Protein function: Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1, signaling is proposed to occur in early endosomes after endocytosis of...

Protein function: Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1, signaling is proposed to occur in early endosomes after endocytosis of...

TIRP is a Toll/interleukin-1 receptor (IL1R, MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4, MIM 603030).[supplied by OMIM, Apr 2004] Protein function: Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I...

TIRP is a Toll/interleukin-1 receptor (IL1R, MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4, MIM 603030).[supplied by OMIM, Apr 2004], Protein function: Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I...

PF-04691502 is an inhibitor of PI3Kalpha, -beta, -delta, and -gamma and mammalian target of rapamycin (mTOR, Kis = 1.8, 2.1, 1.6, 1.9, and 16 nM, respectively, for the human enzymes). It decreases the proliferation of BT-20 breast cancer, SKOV3 ovarian cancer, and U87MG glioblastoma cells (IC50s = 313, 188, and 179...

Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1, signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be...