ATB-337

ATB-337
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10277-1 1 mg -

6 - 10 business days*

48.00€
Cay10277-5 5 mg -

6 - 10 business days*

208.00€
Cay10277-10 10 mg -

6 - 10 business days*

368.00€
Cay10277-50 50 mg -

6 - 10 business days*

1,592.00€
 
Hydrogen sulfide (H2S) is a naturally occurring gasotransmitter with vasodilator and inflammatory... more
Product information "ATB-337"
Hydrogen sulfide (H2S) is a naturally occurring gasotransmitter with vasodilator and inflammatory modulating activity. Non-steroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, diclofenac, and ibuprofen, are some of the most commonly used anti-inflammatory drugs available but exhibit significant side effects, particularly gastric damage, when used chronically. ATB-337 is a hybrid molecule of an H2S donor and the NSAID diclofenac. In rats, diclofenac at 10-50 µmol/kg caused significant gastrointestinal damage, whereas no damage was observed with ATB-337 treatment at the same dose. ATB-337 at 50 µmol/kg does not promote leukocyte adherence to vascular endothelium, an effect observed with diclofenac treatment alone. COX-1 and COX-2 were inhibited with similar efficacy by diclofenac and ABT-337. An increase in expression of the pro-inflammatory mediator TNF-alpha, as well as, the adhesion molecules ICAM-1 and LFA-1 were not observed in rats treated with 50 µmol/kg ABT-337, effects seen with equimolar doses of diclofenac. These results indicate that H2S-releasing derivatives of NSAIDs may prove to be more effective anti-inflammatory agents than traditional NSAIDs alone.Formal Name: 2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid, 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester. CAS Number: 912758-00-0. Synonyms: ACS 15, S-Diclofenac. Molecular Formula: C23H15NCl2O2S3. Formula Weight: 504.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 10 mg/ml. lambdamax: 276, 319, 436 nm. SMILES: O=C(Oc1ccc(cc1)c1ssc(=S)c1)Cc1ccccc1Nc1c(Cl)cccc1Cl. InChi Code: InChI=1S/C23H15Cl2NO2S3/c24-17-5-3-6-18(25)23(17)26-19-7-2-1-4-15(19)12-21(27)28-16-10-8-14(9-11-16)20-13-22(29)31-30-20/h1-11,13,26H,12H2. InChi Key: BRDUXOHVEZVAHI-UHFFFAOYSA-N.
Keywords: ACS 15, S-Diclofenac, 2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid, 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester
Supplier: Cayman Chemical
Supplier-Nr: 10277

Properties

Application: COX-1 inhibitor, COX-2 inhibitor
MW: 504.5 D
Formula: C23H15NCl2O2S3
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 912758-00-0| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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