ATAD2 bromodomain (human recombinant)

ATAD2 bromodomain (human recombinant)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14490-100 100 µg -

6 - 10 business days*

481.00€
 
The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of... more
Product information "ATAD2 bromodomain (human recombinant)"
The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain. These domains function in linking protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as "readers" of histone acetylation marks regulating the transcription of target promoters. ATAD2 is an AAA+ ATPase-containing nuclear transcriptional coactivator for the estrogen and androgen receptors. ATAD2 is highly expressed in several types of tumors and has been proposed to link the E2F and MYC signaling pathways. Binding to the MYC oncogene stimulates its transcriptional activity, leading to the development of aggressive cancers with poor prognosis. ATAD2 is important for the assembly of chromatin modifying complexes and its bromodomain associates with acetylated lysine 14 on histone H3 to regulate the genes required for cell cycle progression.Synonyms: ANCCA, ATPase Family AAA Domain-containing Protein 2. Purity: >90%. Source: recombinant N-terminal GST-tagged protein expressed in E. coli. Amino Acids: 981-1,108 (partial protein). MW: 43.1 kDa. Formulation: (Request formulation change), 50 mM Tris, pH 8.0, containing 150 mM sodium chloride and 20% glycerol. UniProt Accession #: Q6PL18.
Keywords: L16, ATAD2, ANCCA, ANCCA, ATPase family AAA domain-containing protein 2, ATPase family AAA domain-containing protein 2, AAA nuclear coregulator cancer-associated protein, AAA nuclear coregulator cancer-associated protein
Supplier: Cayman Chemical
Supplier-Nr: 14490

Properties

Application: Estrogen and androgen receptor coactivator
Conjugate: No
Host: E.coli
MW: 43,1 kD
Purity: >90%

Handling & Safety

Storage: -80°C
Shipping: -80°C (International: -80°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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